H
Hediye Erdjument-Bromage
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 251
Citations - 80981
Hediye Erdjument-Bromage is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 128, co-authored 240 publications receiving 76640 citations. Previous affiliations of Hediye Erdjument-Bromage include Kettering University.
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Journal ArticleDOI
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
Sonja Krugmann,Karen E. Anderson,S. H. Ridley,N. Risso,A. McGregor,John Coadwell,Keith Davidson,Alicia Eguinoa,Chris D. Ellson,Peter Lipp,Maria Manifava,Nicholas T. Ktistakis,Gavin F. Painter,J.W. Thuring,Mark E. Cooper,Ze-Yi Lim,Andrew B. Holmes,Sophie Dove,Robert H. Michell,Anita Grewal,Arpi Nazarian,Hediye Erdjument-Bromage,Paul Tempst,Len R. Stephens,Phillip T. Hawkins +24 more
TL;DR: It is shown that matrices carrying the tethered homologs of natural phosphoinositides can be used to capture and display multiple phosphoinoskeleton-dependent rearrangements in the cell cytoskeleton and cell shape.
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HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation
Raphael B. Parmigiani,Weisheng Xu,Gisela Venta-Perez,Hediye Erdjument-Bromage,Mariana Yaneva,Paul Tempst,Paul A. Marks +6 more
TL;DR: In this article, the redox regulatory proteins, peroxiredoxin (Prx) I and Prx II are specific targets of histone deacetylases (HDACs) and they are elevated in many cancers and neurodegenerative diseases.
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SAP30, a Novel Protein Conserved between Human and Yeast, Is a Component of a Histone Deacetylase Complex
Yi Zhang,Zu-Wen Sun,Rabah Iratni,Hediye Erdjument-Bromage,Paul Tempst,Michael Hampsey,Danny Reinberg +6 more
TL;DR: The human SAP30 complex is active in deacetylating core histone octamers, but inactive in de acetylating nucleosomal histones due to the inability of the histone binding proteins R bAp46 and RbAp48 to gain access to nucleosome histones.
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A CK2-Dependent Mechanism for Degradation of the PML Tumor Suppressor
Pier Paolo Scaglioni,Thomas M. Yung,Lu Fan Cai,Hediye Erdjument-Bromage,Andrew J. Kaufman,Bhuvanesh Singh,Julie Teruya-Feldstein,Paul Tempst,Pier Paolo Pandolfi +8 more
TL;DR: It is shown that CK2 regulates PML protein levels by promoting its ubiquitin-mediated degradation dependent on direct phosphorylation at Ser517, Consequently, PML mutants that are resistant to CK2 phosphorylated display increased tumor-suppressive functions.
Journal ArticleDOI
Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo
G. Sebastiaan Winkler,Arnold Kristjuhan,Hediye Erdjument-Bromage,Paul Tempst,Jesper Q. Svejstrup +4 more
TL;DR: It is shown that the levels of multiply acetylated histone H3 and H4 in chromatin are decreased in vivo in yeast cells lacking ELP3, and that Elongator can acetylate both core histones and nucleosomal substrates.