H
Hediye Erdjument-Bromage
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 251
Citations - 80981
Hediye Erdjument-Bromage is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 128, co-authored 240 publications receiving 76640 citations. Previous affiliations of Hediye Erdjument-Bromage include Kettering University.
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Journal ArticleDOI
Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus
Wei Li,Jonathan Cooper,Jonathan Cooper,Lu Zhou,Chenyi Yang,Hediye Erdjument-Bromage,David Zagzag,Matija Snuderl,Marc Ladanyi,C. Oliver Hanemann,Pengbo Zhou,Matthias A. Karajannis,Filippo G. Giancotti +12 more
TL;DR: It is found that derepressed CRL4(DCAF1) promotes YAP- and TEAD-dependent transcription by ubiquitylating and, thereby, inhibiting Lats1 and 2 in the nucleus.
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A novel Rad24 checkpoint protein complex closely related to replication factor C.
TL;DR: Analysis of Rad24 in whole cell extracts demonstrated that its mass was considerably greater than its predicted molecular weight, suggesting that Rad24 is a component of a protein complex that may function as a structure-specific sensor in the DNA damage checkpoint pathway.
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The epichaperome is an integrated chaperome network that facilitates tumour survival
Anna Rodina,Tai Wang,Pengrong Yan,Erica DaGama Gomes,Mark Dunphy,Nagavarakishore Pillarsetty,John Koren,John F. Gerecitano,Tony Taldone,Hongliang Zong,Eloisi Caldas-Lopes,Mary L. Alpaugh,Adriana D. Corben,Matthew Riolo,Brad Beattie,Christina Pressl,Radu I Peter,Chao Xu,Robert Trondl,Hardik J. Patel,Fumiko Shimizu,Alexander Bolaender,Chenghua Yang,Palak Panchal,Mohammad F. Farooq,Sarah Kishinevsky,Shanu Modi,Oscar Lin,Feixia Chu,Sujata Patil,Hediye Erdjument-Bromage,Pat Zanzonico,Clifford A. Hudis,Lorenz Studer,Gail J. Roboz,Ethel Cesarman,Leandro Cerchietti,Ross L. Levine,Ari Melnick,Steven M. Larson,Jason S. Lewis,Monica L. Guzman,Gabriela Chiosis,Gabriela Chiosis +43 more
TL;DR: It is found that under conditions of stress, such as malignant transformation fuelled by MYC, the chaperome becomes biochemically ‘rewired’ to form a network of stable, survival-facilitating, high-molecular-weight complexes.
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A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control
Melinda L. Angus-Hill,Alisha Schlichter,Douglas N. Roberts,Hediye Erdjument-Bromage,Paul Tempst,Bradley R. Cairns +5 more
TL;DR: It is proposed that Rsc3 and Rsc30 interact physically but have different roles in targeting or regulating RSC, a yeast remodeler RSC complex that requires their zinc cluster domain.
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Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase.
TL;DR: It is proposed that co-translational domain formation avoids intramolecular misfolding and may be critical in the folding of multidomain proteins.