H
Hediye Erdjument-Bromage
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 251
Citations - 80981
Hediye Erdjument-Bromage is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 128, co-authored 240 publications receiving 76640 citations. Previous affiliations of Hediye Erdjument-Bromage include Kettering University.
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SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex
G. Rasti,Maximilian Becker,Berta N. Vazquez,Maria Espinosa-Alcantud,Irene Fernández-Duran,Andrés Gámez-García,Jessica Gonzalez-Nieto,Laia Bosch-Presegué,Anna Marazuela-Duque,Sandra Segura-Bayona,Alessandro Ianni,Joan Josep Bech-Serra,Michael Scher,Lourdes Serrano,Uma Shankavaram,Hediye Erdjument-Bromage,Paul Tempst,Danny Reinberg,Mireia Olivella,Travis H. Stracker,Carolina De La Torre,Alejandro Vaquero +21 more
TL;DR: During stress, SIRT1 signaling ensures a global control of DNA damage signaling through PP4, which regulates γH2AX and RPA2 phosphorylation, two key events in the signaling ofDNA damage and repair by HR.
Journal ArticleDOI
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
Anna Rodina,Chander Singh Digwal,Suhasini Joshi,Yogita D Patel,Anand Ramaian Santhaseela,Sadık Bay,Swathi Merugu,Pengrong Yan,Chenghua Yang,Tanaya Roychowdhury,Palak Kiritbhai Panchal,Liza Shrestha,Ya Lin Kang,Sahil Sharma,Justina Almodovar,Adriana D. Corben,Mary L. Alpaugh,Shanu Modi,Monica L. Guzman,Teng Fei,Tony Taldone,Stephen D. Ginsberg,Hediye Erdjument-Bromage,Thomas A. Neubert,Katia Manova-Todorova,Meng-Fu Bryan Tsou,Jason C. Young,Tai-Hsiang Wang,Gabriela Chiosis +28 more
TL;DR: In this article , the epichaperome-based "omics platform" was developed to identify protein-protein interaction (PPI) network dysfunctions in cancer cells and derive a context-dependent mechanism by which cancer cells enhance the fitness of mitotic protein networks.
Adipocyte-specif ic transcription factor ARF6isa heterodimeric complex oftwonuclear hormone receptors, PPARyandRXRoe
TL;DR: Results suggest that PPARy2servesaunique function among PPARfamily members asanimportant regulator ofadipocyte-specific gene expression, and is suggested to be the predominant form expressed inadipose tissue.
Human Mob Proteins Regulate the NDR1 and NDR2
TL;DR: In this paper, the authors identify a unique class of human kinase-activating subunits that may be functionally analagous to cyclins and demonstrate that NDR1 and NDR2 partially colocalize with human Mob2 in HeLa cells and confirm the NDRMob interactions in cell extracts.
Posted ContentDOI
Knockout of cardiolipin synthase disrupts postnatal cardiac development by inhibiting the maturation of mitochondrial cristae
Mindong Ren,Yang Xu,Colin K.L. Phoon,Hediye Erdjument-Bromage,Thomas A. Neubert,Michael Schlame +5 more
TL;DR: In this article , a cardiomyocyte-restricted knockout of cardiolipin synthase (Crls1) was used to study the postnatal development of the heart.