H
Hediye Erdjument-Bromage
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 251
Citations - 80981
Hediye Erdjument-Bromage is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 128, co-authored 240 publications receiving 76640 citations. Previous affiliations of Hediye Erdjument-Bromage include Kettering University.
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Journal ArticleDOI
High-sensitivity sequencing of large proteins: Partial structure of the rapamycin-FKBP12 target
TL;DR: Developments comprise higher‐sensitivity chemical sequencing through background reduction; improved peptide recovery from rapid in situ digests of nanogram amount, nitrocellulose‐bound proteins; and accurate UV spectroscopic identification of Trp‐ and Cys‐containing peptides.
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Mutual targeting of mediator and the TFIIH kinase Kin28.
Benjamin W. Guidi,Gudrun Bjornsdottir,Daniel Hopkins,Lynne Lacomis,Hediye Erdjument-Bromage,Paul Tempst,Lawrence C. Myers +6 more
TL;DR: It is determined that the subunits of TFIIK are sufficient for Mediator to enhance Kin28 CTD kinase activity and that Mediator enhances phosphorylation of a glutathione S-transferase-CTD fusion protein, despite the absence of multiple Mediator and/or TFIIH interactions with polymerase.
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ERS-24, a Mammalian v-SNARE Implicated in Vesicle Traffic between the ER and the Golgi
Inbok Paek,L Orci,M Ravazzola,Hediye Erdjument-Bromage,Mylène Amherdt,Paul Tempst,Thomas H. Söllner,James E. Rothman +7 more
TL;DR: ERS-24 has significant sequence homology to Sec22p, a v-SNARE in Saccharomyces cerevisiae required for transport between the ER and the Golgi, and it is enriched in transport vesicles associated with these organelles.
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The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme.
Thomas Hon,Hee Chul Lee,Angela Hach,Jill L. Johnson,Elizabeth A. Craig,Hediye Erdjument-Bromage,Paul Tempst,Li Zhang +7 more
TL;DR: The results suggest that Ssa-Ydj1 and Sro9 act together to mediate Hap1 repression in the absence of heme and that molecular chaperones promote heme regulation of Hap 1 by a mechanism distinct from the mechanism of steroid signaling.
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Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma.
Lisa Giulino-Roth,Herman van Besien,Tanner Dalton,Jennifer Totonchy,Anna Rodina,Tony Taldone,Alexander Bolaender,Hediye Erdjument-Bromage,Jouliana Sadek,Amy Chadburn,Matthew J. Barth,Filemon S. Dela Cruz,Allison R. Rainey,Andrew L. Kung,Gabriela Chiosis,Ethel Cesarman +15 more
TL;DR: Support is provided for Hsp90 as a therapeutic target in BL and the potential for combination therapy with PU-H71 and inhibitors of PI3K/AKT/mTOR is suggested, suggesting the importance of this pathway in BL.