H
Hediye Erdjument-Bromage
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 251
Citations - 80981
Hediye Erdjument-Bromage is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Histone code & Histone methyltransferase. The author has an hindex of 128, co-authored 240 publications receiving 76640 citations. Previous affiliations of Hediye Erdjument-Bromage include Kettering University.
Papers
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Journal ArticleDOI
PU.1 and a TTTAAA element in the myeloid defensin-1 promoter create an operational TATA box that can impose cell specificity onto TFIID function.
Mariana Yaneva,Serena Kippenberger,Nan Wang,Qin Su,Margaret McGarvey,Arpi Nazarian,Lynne Lacomis,Hediye Erdjument-Bromage,Paul Tempst +8 more
TL;DR: D1BP is identified, biochemically and functionally, as GA-binding protein (GABP)α/ GABPβ, which suggests how the myeloid def1 promoter may have evolutionarily acquired its current properties.
Journal ArticleDOI
N-Terminal Amino Acid Sequence Determination of Proteins by N-Terminal Dimethyl Labeling: Pitfalls and Advantages When Compared with Edman Degradation Sequence Analysis.
Elizabeth Chang,Sergei Pourmal,Chun Zhou,Rupesh Kumar,Marianna Teplova,Nikola P. Pavletich,Kenneth J. Marians,Hediye Erdjument-Bromage +7 more
TL;DR: Application of this approach on protein domains, generated by limited proteolysis of overexpressed proteins, confirms that it is a universal labeling technique and is very sensitive when compared with Edman sequencing.
Proceedings ArticleDOI
Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex
Anna Rodina,Kamalika Moulick,James H. Ahn,Hongliang Zong,Leandro Cerchietti,Erica Gomes DaGama,Eloisi Caldas-Lopes,Kristin Beebe,Fabiana Perna,Katerina Hatzi,Ly P. Vu,Xinyang Zhao,Danuta Zatorska,Tony Taldone,Peter Smith-Jones,Mary L. Alpaugh,Steven S. Gross,Nagavarakishore Pillarsetty,Thomas Ku,Jason S. Lewis,Steven M. Larson,Ross L. Levine,Hediye Erdjument-Bromage,Monica L. Guzman,Stephen D. Nimer,Ari Melnick,Len Neckers,Gabriela Chiosis +27 more
TL;DR: The data suggest that Hsp90 may execute functions necessary to maintain the malignant phenotype, and experimental evidence is presented for an additional role; that is, to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes.
Patent
Rat proteins that exhibit rapamycin-dependant binding to FKBP12
TL;DR: In this article, a protein complex containing 245 kDa and 35 kDa components, designated RAFT1 and RAFT2 (for Rapamycin And FKBP12 Target), was obtained and found to encode a 289 kDa protein that is 43% and 39% identical to TOR2 and TOR1, respectively.
Journal ArticleDOI
High-level expression of a full-length Eph receptor.
Sari Paavilainen,David Grandy,Eveliina Karelehto,Elizabeth Chang,Petri Susi,Petri Susi,Hediye Erdjument-Bromage,Dimitar B. Nikolov,Juha P. Himanen +8 more
TL;DR: An expression system for producing the full-length human EphA2 receptor is developed and the purified receptor was shown to retain its biological activity in terms of both binding to its functional ligands and being able to auto-phosphorylate the key tyrosine residues of the cytoplasmic kinase domain.