H
Hee Kyung Hong
Researcher at Northwestern University
Publications - 29
Citations - 6227
Hee Kyung Hong is an academic researcher from Northwestern University. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 18, co-authored 28 publications receiving 5451 citations. Previous affiliations of Hee Kyung Hong include University of Texas Southwestern Medical Center & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Seung Hee Yoo,Shin Yamazaki,Shin Yamazaki,Phillip L. Lowrey,Kazuhiro Shimomura,Caroline H. Ko,Caroline H. Ko,Ethan D. Buhr,Sandra M. Siepka,Hee Kyung Hong,Won Jun Oh,Ook Joon Yoo,Michael Menaker,Joseph S. Takahashi +13 more
TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.
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The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease
TL;DR: Together, these studies set the scene for applying the knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis
Kathryn Moynihan Ramsey,Jun Yoshino,Cynthia S. Brace,Dana Abrassart,Yumiko Kobayashi,Yumiko Kobayashi,Biliana Marcheva,Hee Kyung Hong,Jason L. Chong,Ethan D. Buhr,Choogon Lee,Joseph S. Takahashi,Shin-ichiro Imai,Joseph Bass,Joseph Bass +14 more
TL;DR: It is reported that both the rate-limiting enzyme in mammalian Nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice.
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Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm
Seung Hee Yoo,Jennifer A. Mohawk,Sandra M. Siepka,Yongli Shan,Seong Kwon Huh,Hee Kyung Hong,Izabela Kornblum,Vivek Kumar,Nobuya Koike,Ming Xu,Justin Nussbaum,Xinran Liu,Zheng Chen,Zhijian J. Chen,Carla B. Green,Carla B. Green,Joseph S. Takahashi +16 more
TL;DR: The balance and cellular compartmentalization of competing E3 ligases for CRY determine circadian period of the clock in mammals.
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Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice
Erin L. McDearmon,Kush N. Patel,Caroline H. Ko,Caroline H. Ko,Jacqueline A. Walisser,Andrew C. Schook,Jason L. Chong,Lisa D. Wilsbacher,Eun Joo Song,Hee Kyung Hong,Christopher A. Bradfield,Joseph S. Takahashi +11 more
TL;DR: Circadian rhythms of wheel-running activity were restored in brain-rescued Bmal1–/– mice in a conditional manner; however, activity levels and body weight were lower than those of wild-type mice.