H
Hongjiang Wu
Researcher at University of California, San Diego
Publications - 20
Citations - 1521
Hongjiang Wu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chromogranin A & CREB. The author has an hindex of 16, co-authored 19 publications receiving 1462 citations. Previous affiliations of Hongjiang Wu include Veterans Health Administration & University of California, Berkeley.
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Journal ArticleDOI
Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
Sushil K. Mahata,Daniel T. O'Connor,Manjula Mahata,Seung Hyun Yoo,Laurent Taupenot,Hongjiang Wu,B. M. Gill,R J Parmer +7 more
TL;DR: This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons.
Journal ArticleDOI
Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog
Nitish R. Mahapatra,Daniel T. O'Connor,Sucheta M. Vaingankar,Amiya P. Sinha Hikim,Manjula Mahata,Saugata Ray,Eugenie Staite,Hongjiang Wu,Yusu Gu,Nancy D. Dalton,Brian P. Kennedy,Michael G. Ziegler,John Ross,Sushil K. Mahata +13 more
TL;DR: Loss of the physiological "brake" catestatin in Chga mice coupled with dysregulation of transmitter storage and release may act in concert to alter autonomic control of the circulation in vivo, eventuating in hypertension.
Journal ArticleDOI
Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway.
TL;DR: It is demonstrated that chromogranin A is a substrate for the endogenous endoproteases PC1 and furin in vivo, and that such processing influences its trafficking into the regulated secretory pathway; furthermore, lack of change in chromoganin B and secretogran in II cleavage after diminution of PCl suggests that the action of PC1 on chromog Granin A may be specific within the chromog Cranin/secretogranIn protein family.
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Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression.
TL;DR: The results suggest that this complex gene is encoded by exon modules with evolutionary links to homologous modules in other chromogranin/secretogran in protein family members, and that the 5'-flanking region of the gene is sufficient to confer neuroendocrine tissue-specific expression of the chromogrannin A gene.
Journal ArticleDOI
Formation of the Catecholamine Release-inhibitory Peptide Catestatin from Chromogranin A: DETERMINATION OF PROTEOLYTIC CLEAVAGE SITES IN HORMONE STORAGE GRANULES *
Carolyn V. Livsey Taylor,Laurent Taupenot,Sushil K. Mahata,Manjula Mahata,Hongjiang Wu,Sukkid Yasothornsrikul,Thomas Toneff,Carlo Caporale,Qijiao Jiang,Robert J. Parmer,Vivian Hook,Daniel T. O'Connor +11 more
TL;DR: It is concluded that catestatin is cleaved extensively in vivo, and the peptide is released by exocytosis as demonstrated by radioimmunoassay of size-fractionated chromaffin granules.