H
Huib N. Caron
Researcher at University of Amsterdam
Publications - 74
Citations - 10178
Huib N. Caron is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 41, co-authored 72 publications receiving 9388 citations. Previous affiliations of Huib N. Caron include Boston Children's Hospital.
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Journal ArticleDOI
Histone deacetylases (HDACs): characterization of the classical HDAC family
Annemieke J.M. de Ruijter,Albert H. van Gennip,Huib N. Caron,Stephan Kemp,André B.P. van Kuilenburg +4 more
TL;DR: In this paper, a comprehensive overview of the structure, function and tissue distribution of members of the classical histone deacetylase (HDAC) family, in order to gain insight into the regulation of gene expression through HDAC activity is presented.
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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Jan J. Molenaar,Jan Koster,Danny A. Zwijnenburg,Peter van Sluis,Linda J. Valentijn,Ida van der Ploeg,Mohamed Hamdi,Johan van Nes,Bart A. Westerman,Jennemiek van Arkel,Marli E. Ebus,Franciska Haneveld,Arjan Lakeman,Linda Schild,Piet Molenaar,Peter Stroeken,Max M. van Noesel,Ingrid Øra,Ingrid Øra,Evan E. Santo,Huib N. Caron,Ellen M. Westerhout,Rogier Versteeg +22 more
TL;DR: The genomic landscape of neuroblastoma reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours.
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The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains
Huib N. Caron,Barbera D. C. van Schaik,Merlijn van der Mee,Frank Baas,Gregory J. Riggins,Peter van Sluis,Marie-Christine Hermus,Ronald van Asperen,Kathy Boon,P.A. Voûte,S. H. Heisterkamp,Antoine H. C. van Kampen,Rogier Versteeg +12 more
TL;DR: The Human Transcriptome Map (HPM) as mentioned in this paper is a tool to search for genes that are overexpressed or silenced in cancer using the SAGE serial analysis of gene expression.
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Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features
Marcel Kool,Jan Koster,Jens Bunt,Nancy E. Hasselt,Arjan Lakeman,Peter van Sluis,Dirk Troost,Netteke A. Y. Schouten-van Meeteren,Huib N. Caron,Jacqueline Cloos,Alan Mrsić,Bauke Ylstra,Wiesława Grajkowska,Wolfgang Hartmann,Torsten Pietsch,David W. Ellison,Steven C. Clifford,Rogier Versteeg +17 more
TL;DR: The new medulloblastoma classification presented in this study will greatly enhance the understanding of this heterogeneous disease and enable a better selection and evaluation of patients in clinical trials, and it will support the development of new molecular targeted therapies.
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Neuroblastoma: Biology, Prognosis, and Treatment
TL;DR: This article summarizes the understanding of neuroblastoma biology and prognostic features and discusses their impact on current and proposed risk stratification schemas, risk-based therapeutic approaches, and the development of novel therapies for patients at high risk for failure.