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I. Quintus Molenaar
Researcher at Utrecht University
Publications - 168
Citations - 6395
I. Quintus Molenaar is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Pancreatic cancer. The author has an hindex of 34, co-authored 119 publications receiving 4432 citations. Previous affiliations of I. Quintus Molenaar include University Medical Center Groningen & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj,Chang-Il Hwang,Chang-Il Hwang,Lindsey A. Baker,Lindsey A. Baker,Iok In Christine Chio,Iok In Christine Chio,Dannielle D. Engle,Dannielle D. Engle,Vincenzo Corbo,Vincenzo Corbo,Myrthe Jager,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Hervé Tiriac,Hervé Tiriac,Mona S. Spector,Mona S. Spector,Ana Gracanin,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Kenneth H. Yu,Ruben van Boxtel,Meritxell Huch,Keith Rivera,John P. Wilson,Michael E. Feigin,Michael E. Feigin,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Christine M. Ardito-Abraham,Christine M. Ardito-Abraham,Michael Ludwig,Michael Ludwig,Ela Elyada,Ela Elyada,Brinda Alagesan,Brinda Alagesan,Brinda Alagesan,Giulia Biffi,Giulia Biffi,Georgi N. Yordanov,Georgi N. Yordanov,Bethany Delcuze,Bethany Delcuze,Brianna Creighton,Brianna Creighton,Kevin Wright,Kevin Wright,Young-Kyu Park,Young-Kyu Park,Folkert H.M. Morsink,I. Quintus Molenaar,Inne H.M. Borel Rinkes,Edwin Cuppen,Yuan Hao,Ying Jin,Isaac J. Nijman,Christine A. Iacobuzio-Donahue,Steven D. Leach,Darryl J. Pappin,Molly Hammell,David S. Klimstra,Olca Basturk,Ralph H. Hruban,G. J. A. Offerhaus,Robert G.J. Vries,Hans Clevers,David A. Tuveson,David A. Tuveson,David A. Tuveson +73 more
TL;DR: Comprehensive transcriptional and proteomic analyses of murine pancreatic organoids revealed genes and pathways altered during disease progression that demonstrate that organoids are a facile model system to discover characteristics of this deadly malignancy.
Journal ArticleDOI
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2) : a multicentre, patient-blinded, randomised controlled phase 2/3 trial
Jony van Hilst,Thijs de Rooij,Koop Bosscha,David J. Brinkman,Susan van Dieren,Marcel G. W. Dijkgraaf,Michael F. Gerhards,Ignace H. J. T. de Hingh,Tom M. Karsten,D.J. Lips,D.J. Lips,Misha D. P. Luyer,Olivier R. Busch,Sebastiaan Festen,Marc G. Besselink,Hendrik A. Marsman,Thomas M. van Gulik,Dennis A. Wicherts,Wietse J. Eshuis,Luna A Stibbe,Els Jm Nieveen van Dijkum,Janine E Van Hooft,Paul Fockens,Hanneke W. M. van Laarhoven,Johanna W. Wilmink,Marcel J Van de Vijver,Maarten F. Bijlsma,Joanne Verheij,C. Yung Nio,Krijn P. van Lienden,Geertjan van Tienhoven,Annuska Schoorlemmer,Geert-Jan Creemers,Casper H.J. van Eijck,Bas Groot Koerkamp,Marco J. Bruno,Ferry A.L.M. Eskens,Joost J. Nuyttens,Chulja Pek,George P. van der Schelling,Tom C.J. Seerden,Gijs A. Patijn,Vincent B. Nieuwenhuijs,Jan Willem B. de Groot,Bert A. Bonsing,Alexander L. Vahrmeijer,R.-J. Swijnenburg,J. Sven D. Mieog,Erwin van der Harst,Matthijs Den Dulk,Steven W.M. Olde Damink,Cees H. Dejong,Ronald Van Dam,Judith Mpgm De Vos,Mike Sl Liem,Cees J. H. M. van Laarhoven,Harry van Goor,Peter B. van den Boezem,B. Marion van der Kolk,Martijn Wj Stommel,John J. Hermans,Erwin J M van Geenen,Sandra A Radema,Lodewijk A.A. Brosens,Joris J. Scheepers,Daphne Roos,Djamilla Boerma,Wouter W. te Riele,Hjalmar C. van Santvoort,Thomas L. Bollen,Fanny Wit,I. Quintus Molenaar,Nadia Haj Mohammad,Maarten S. van Leeuwen,Annemarie Roele,Kees P De Jong,Vincent E de Meijer,Joost M. Klaase,Geert Kazemier,Babs M Zonderhuis,Freek Daams,Martijn R. Meijerink,Anouk E J Latenstein,L. Bengt van Rijssen,Carolijn L.M.A. Nota,Emo Van Halsema,Eran van Veldhuisen,Jantien A. Vogel,Kiki Janssen,Lianne Scholten,Lois A. Daamen,Marieke S. Walma,Marin Strijker,Mariska Prins,Maurice J. W. Zwart,Mustafa Suker,Steffi J.E. Rombouts,Timothy H. Mungroop,F. Vissers,Maarten Korrel +99 more
TL;DR: This multicentre, patient-blinded, parallel-group, randomised controlled phase 2/3 trial was performed in four centres in the Netherlands to assess whether laparoscopic pancreatoduodenectomy could reduce time to functional recovery compared with open pancreatic fistula.
Journal ArticleDOI
Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial
David W da Costa,Stefan A.W. Bouwense,Nicolien J. Schepers,Marc G. Besselink,Hjalmar C. van Santvoort,Sandra van Brunschot,Olaf J. Bakker,Thomas L. Bollen,Cornelis H. C. Dejong,Harry van Goor,Marja A. Boermeester,Marco J. Bruno,Casper H.J. van Eijck,Robin Timmer,Bas L. Weusten,Esther C. J. Consten,Menno A. Brink,B W Marcel Spanier,Ernst Jan Spillenaar Bilgen,Vincent B. Nieuwenhuijs,H. Sijbrand Hofker,Camiel Rosman,Annet M. C. J. Voorburg,Koop Bosscha,Peter van Duijvendijk,Jos J G M Gerritsen,Joos Heisterkamp,Ignace H. J. T. de Hingh,Ben J.M. Witteman,Philip M Kruyt,Joris J. Scheepers,I. Quintus Molenaar,Alexander F. Schaapherder,Eric R. Manusama,Laurens A. van der Waaij,Josephus Marinus Jacobus van Unen,Marcel G. W. Dijkgraaf,Bert van Ramshorst,Hein G. Gooszen,Djamila Boerma +39 more
TL;DR: Same-admission cholecystectomy reduced the rate of recurrent gallstone-related complications in patients with mild gallstone pancreatitis, with a very low risk of choleCystectomy- related complications.
Journal ArticleDOI
Alternative Fistula Risk Score for Pancreatoduodenectomy (a-FRS): Design and International External Validation.
Timothy H. Mungroop,L. Bengt van Rijssen,David van Klaveren,F. Jasmijn Smits,Victor van Woerden,R. Linnemann,Matteo De Pastena,Sjors Klompmaker,Giovanni Marchegiani,Brett L. Ecker,Susan van Dieren,Bert A. Bonsing,Olivier R. Busch,Ronald M. van Dam,Joris I. Erdmann,Casper H.J. van Eijck,Michael F. Gerhards,Harry van Goor,Erwin van der Harst,Ignace H. J. T. de Hingh,Koert P. de Jong,Geert Kazemier,Misha D. P. Luyer,Awad Shamali,Salvatore Barbaro,T. Armstrong,Arjun Takhar,Zaed Hamady,Joost M. Klaase,Daan J. Lips,I. Quintus Molenaar,Vincent B. Nieuwenhuijs,Coen G. Rupert,Hjalmar C. van Santvoort,Joris J. Scheepers,George P. van der Schelling,Claudio Bassi,Charles M. Vollmer,Ewout W. Steyerberg,Mohammed Abu Hilal,Bas Groot Koerkamp,Marc G. Besselink +41 more
TL;DR: In this paper, the authors developed an alternative fistula risk score (a-FRS) for postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, without blood loss as a predictor.
Journal ArticleDOI
Defining and Predicting Early Recurrence in 957 Patients With Resected Pancreatic Ductal Adenocarcinoma.
Vincent P. Groot,Vincent P. Groot,Georgios Gemenetzis,Alex B. Blair,Roberto J. Rivero-Soto,Jun Yu,Ammar A. Javed,Richard A. Burkhart,Inne H.M. Borel Rinkes,I. Quintus Molenaar,John L. Cameron,Matthew J. Weiss,Christopher L. Wolfgang,Jin He +13 more
TL;DR: A recurrence-free interval of 12 months is the optimal threshold for differentiating between early and late recurrence, based on subsequent prognosis, in patients undergoing pancreatic ductal adenocarcinoma resection.