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Iliano V. Coutinho-Abreu
Researcher at National Institutes of Health
Publications - 45
Citations - 1095
Iliano V. Coutinho-Abreu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Leishmania & Leishmania major. The author has an hindex of 16, co-authored 41 publications receiving 825 citations. Previous affiliations of Iliano V. Coutinho-Abreu include Federal University of Pernambuco & University of Notre Dame.
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Transgenesis and paratransgenesis to control insect-borne diseases: current status and future challenges.
TL;DR: The current status of transgenesis and paratransgenesis is highlighted, pointing out advantages and constraints, and issues that need to be resolved are explored before the establishment of transGenesis andParatransGenesis as tools to prevent vector-borne diseases.
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Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β
Ranadhir Dey,Amritanshu B. Joshi,Fabiano Oliveira,Lais Pereira,Lais Pereira,Anderson B. Guimarães-Costa,Tiago D. Serafim,Waldionê de Castro,Iliano V. Coutinho-Abreu,Parna Bhattacharya,Shannon Townsend,Hamide Aslan,Alec Perkins,Subir Karmakar,Nevien Ismail,Morgan Karetnick,Claudio Meneses,Robert Duncan,Hira L. Nakhasi,Jesus G. Valenzuela,Shaden Kamhawi +20 more
TL;DR: It is demonstrated that gut microbes from the sand fly are egested into host skin alongside Leishmania parasites, indicating that both gut microbiota and IL-1β are important for the establishment of Leishmaniasis infections.
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Sequential blood meals promote Leishmania replication and reverse metacyclogenesis augmenting vector infectivity.
Tiago D. Serafim,Iliano V. Coutinho-Abreu,Fabiano Oliveira,Claudio Meneses,Shaden Kamhawi,Jesus G. Valenzuela +5 more
TL;DR: It is shown that ingestion of a second uninfected blood meal by Leishmania-infected sand flies triggers dedifferentiation of metacyclic promastigotes to a replicative form, termed the retroleptomonad promastsigote, which amplifies parasite numbers in the flies.
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A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing.
Wen Wei Zhang,Subir Karmakar,Sreenivas Gannavaram,Ranadhir Dey,Patrick Lypaczewski,Nevien Ismail,Abid Siddiqui,Vahan Simonyan,Fabiano Oliveira,Iliano V. Coutinho-Abreu,Thiago DeSouza-Vieira,Claudio Meneses,James Oristian,Tiago D. Serafim,Abu Musa,Risa Nakamura,Noushin Saljoughian,Greta Volpedo,Monika Satoskar,Monika Satoskar,Sanika Satoskar,Sanika Satoskar,Pradeep K. Dagur,J. Philip McCoy,Shaden Kamhawi,Jesus G. Valenzuela,Shinjiro Hamano,Abhay R. Satoskar,Greg Matlashewski,Hira L. Nakhasi +29 more
TL;DR: An attenuated knock-out Leishmania (LmCen−/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmanniasis is engineer.
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Transmission blocking vaccines to control insect-borne diseases: a review
TL;DR: In this review, many of the TBV strategies against insect-borne pathogens and their respective ramification with regards to the immune response of the vertebrate host are discussed.