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Ioannis Theodorou
Researcher at French Institute of Health and Medical Research
Publications - 79
Citations - 4482
Ioannis Theodorou is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 29, co-authored 75 publications receiving 4228 citations. Previous affiliations of Ioannis Theodorou include Centre national de la recherche scientifique.
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Journal ArticleDOI
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
Jorge R. Almeida,David Price,David Price,Laura Papagno,Zaïna Aït Arkoub,Delphine Sauce,Ethan Bornstein,Tedi E. Asher,Assia Samri,Aurélie Schnuriger,Ioannis Theodorou,Dominique Costagliola,Christine Rouzioux,Henri Agut,Anne-Geneviève Marcelin,Daniel C. Douek,Brigitte Autran,Victor Appay +17 more
TL;DR: It is shown that B27-KK10–specific CD8+ T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity, which constitute the basis for effective control of HIV-1 replication.
Journal ArticleDOI
Infections in 252 patients with common variable immunodeficiency.
Eric Oksenhendler,Laurence Gérard,Claire Fieschi,Marion Malphettes,Gael Mouillot,Roland Jaussaud,Jean-François Viallard,Martine Gardembas,Lionel Galicier,Nicolas Schleinitz,Felipe Suarez,Pauline Soulas-Sprauel,Eric Hachulla,Arnaud Jaccard,Anaelle Gardeur,Ioannis Theodorou,Claire Rabian,Patrice Debré +17 more
TL;DR: Although reduced within the past decade, the delay of diagnosis of common variable immunodeficiency remains unacceptable and recurrence of upper respiratory tract infection or pneumonia should lead to systematic evaluation of serum immunoglobulin.
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Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.
Sophie Faure,Laurence Meyer,Dominique Costagliola,Céline Vaneensberghe,Emmanuelle Génin,Brigitte Autran,Jean-François Delfraissy,David H. McDermott,Philip M. Murphy,Patrice Debré,Ioannis Theodorou,Christophe Combadière,Christophe Combadière,Christophe Combadière +13 more
TL;DR: HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes, indicating a recessive genetic risk factor in HIV/AIDS.
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Cutting Edge: Increased NK Cell Activity in HIV-1-Exposed but Uninfected Vietnamese Intravascular Drug Users
Daniel Scott-Algara,Lien X Truong,Pierre Versmisse,Annie David,Tram T. Luong,Ngai V Nguyen,Ioannis Theodorou,Françoise Barré-Sinoussi,Gianfranco Pancino +8 more
TL;DR: The finding of an enhanced NK cell function in EU IDUs, especially compared with IDUs who became HIV-1 infected, supports the hypothesis that NK cells contribute to the protection against HIV- 1 infection.
Journal ArticleDOI
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
Hyun Hor,Hyun Hor,Zoltán Kutalik,Zoltán Kutalik,Yves Dauvilliers,Armand Valsesia,Armand Valsesia,Armand Valsesia,Gert J. Lammers,Claire E H M Donjacour,Alex Iranzo,Joan Santamaria,Rosa Peraita Adrados,José L. Vicario,Sebastiaan Overeem,Isabelle Arnulf,Ioannis Theodorou,Poul Jennum,Stine Knudsen,Claudio L. Bassetti,Johannes Mathis,Michel Lecendreux,Geert Mayer,Peter Geisler,Antonio Benetó,Brice Petit,Corinne Pfister,Julie Vienne Bürki,Gérard Didelot,Michel Billiard,Guadalupe Ercilla,Willem Verduijn,Frans H.J. Claas,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Vincent Mooser,Raphael Heinzer,Jacques S. Beckmann,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Mehdi Tafti,Mehdi Tafti +43 more
TL;DR: An unexpected protective HLA haplotype is found near HLA-DQA2, which suggests a virtually causal involvement of the HLA region in narcolepsy susceptibility.