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Ivan Zanoni
Researcher at Boston Children's Hospital
Publications - 112
Citations - 6957
Ivan Zanoni is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 36, co-authored 106 publications receiving 5323 citations. Previous affiliations of Ivan Zanoni include Harvard University & University of Milan.
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Journal ArticleDOI
Innate immune pattern recognition: a cell biological perspective.
TL;DR: This review highlights aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
Journal ArticleDOI
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
Ivan Zanoni,Renato Ostuni,Lorri R. Marek,Simona Barresi,Roman Barbalat,Gregory M. Barton,Francesca Granucci,Jonathan C. Kagan +7 more
TL;DR: It is reported that the plasma membrane localized Pattern Recognition Receptor (PRR) CD14 is required for the microbe-induced endocytosis of TLR4, and this innate immune trafficking cascade illustrates how pathogen detection systems operate to induce both membrane transport and signal transduction.
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An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Ivan Zanoni,Ivan Zanoni,Yunhao Tan,Marco Di Gioia,Achille Broggi,Jianbin Ruan,Jianjin Shi,Carlos A. Donado,Feng Shao,Hao Wu,James R. Springstead,Jonathan C. Kagan +11 more
TL;DR: It is reported that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which is called “hyperactive” and induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxP APC and bacterial lipopolysaccharide (LPS).
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CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
Ivan Zanoni,Renato Ostuni,Giusy Capuano,Maddalena Collini,Michele Caccia,Antonella Ronchi,Marcella Rocchetti,Francesca Mingozzi,Maria Foti,Giuseppe Chirico,Barbara Costa,Antonio Zaza,Paola Ricciardi-Castagnoli,Paola Ricciardi-Castagnoli,Francesca Granucci +14 more
TL;DR: It is shown that mouse dendritic cell stimulation with lipopolysaccharide (LPS) induces Src-family kinase and phospholipase Cγ2 activation, influx of extracellular Ca2+ and calcineurin-dependent nuclear NFAT translocation, and LPS-induced NFAT activation via CD14 is necessary to cause the apoptotic death of terminally differentiateddendritic cells.
Journal ArticleDOI
Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Achille Broggi,Sreya Ghosh,Benedetta Sposito,Benedetta Sposito,Roberto Spreafico,Fabio Balzarini,Fabio Balzarini,Antonino Lo Cascio,Antonino Lo Cascio,Nicola Clementi,Maria De Santis,Nicasio Mancini,Francesca Granucci,Ivan Zanoni,Ivan Zanoni +14 more
TL;DR: A strong rationale is provided for rethinking the pathophysiological role of IFN-λ and its possible use in clinical practice against endemic viruses, such as influenza virus as well as the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.