J
J. Michael Andresen
Researcher at Massachusetts Institute of Technology
Publications - 16
Citations - 2404
J. Michael Andresen is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Ataxin 1 & Polyglutamine tract. The author has an hindex of 13, co-authored 16 publications receiving 2272 citations. Previous affiliations of J. Michael Andresen include Baylor College of Medicine & University of Minnesota.
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Journal ArticleDOI
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein
Julian Borrow,Vincent P. Stanton,J. Michael Andresen,Reinhard Becher,Frederick G. Behm,Raju S.K. Chaganti,Curt I. Civin,Christine M. Disteche,Ian D. Dubé,Anna Marie Frischauf,Doug Horsman,Felix Mitelman,Stefano Volinia,Ann E. Watmore,David E. Housman +14 more
TL;DR: It is suggested that MOZ may represent a chromatin-associated acetyltransferase, and the possibility that a dominant MOZ–CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation is raised.
Journal ArticleDOI
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Javier Gayán,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,J. B. Penney,James F. Gusella,Jang Ho Cha,Michael C. Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Marcy E. MacDonald,Anne B. Young,J. Michael Andresen,David E. Housman,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyo,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Adam M. Brickman,Denise Krch,Shelley Peery,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyeri +57 more
TL;DR: A model estimated the components of additive genetic, shared environment, and nonshared environment variances confirming that approximately 40% of the variance remaining in onset age is attributable to genes other than the HD gene and 60% is environmental.
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RORα-Mediated Purkinje Cell Development Determines Disease Severity in Adult SCA1 Mice
Heliane G. Serra,Lisa A. Duvick,Tao Zu,Kerri M. Carlson,Sam Stevens,Nathan D. Jorgensen,A. S. Lysholm,Eric N. Burright,Huda Y. Zoghbi,H. Brent Clark,J. Michael Andresen,Harry T. Orr +11 more
TL;DR: RORalpha and Tip60 have a role in SCA1 and suggest a mechanism by which compromising cerebellar development contributes to severity of neurodegeneration in an adult.
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SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Lisa A. Duvick,Justin A. Barnes,Blake A. Ebner,Smita Agrawal,J. Michael Andresen,Janghoo Lim,Glenn J. Giesler,Huda Y. Zoghbi,Harry T. Orr +8 more
TL;DR: It is shown that replacing Ser776 with a phosphomimicking Asp converted ATXN1 with a wild-type glutamine tract into a pathogenic protein, supporting a model where pathogenesis involves changes in regions of the protein in addition to the polyglutamine tract.
Journal ArticleDOI
Symptom dimensions in OCD: item-level factor analysis and heritability estimates.
Hilga Katerberg,Kevin L. Delucchi,S. Evelyn Stewart,Christine Lochner,Damiaan Denys,Denise Egan Stack,J. Michael Andresen,Jon E. Grant,Suck Won Kim,Kyle A. Williams,Johan A. den Boer,Anton J.L.M. van Balkom,Johannes H. Smit,Patricia van Oppen,Annemiek Polman,Michael A. Jenike,Dan J. Stein,Dan J. Stein,Carol A. Mathews,Danielle C. Cath +19 more
TL;DR: In this article, the authors conducted several factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) to reduce the phenotypic heterogeneity of OCD for genetic, clinical and translational studies.