S
Sandra Wiktorski
Researcher at Indiana University – Purdue University Indianapolis
Publications - 2
Citations - 822
Sandra Wiktorski is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Age of onset & Heritability. The author has an hindex of 2, co-authored 2 publications receiving 769 citations.
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Journal ArticleDOI
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Javier Gayán,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,J. B. Penney,James F. Gusella,Jang Ho Cha,Michael C. Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Marcy E. MacDonald,Anne B. Young,J. Michael Andresen,David E. Housman,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyo,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Adam M. Brickman,Denise Krch,Shelley Peery,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyeri +57 more
TL;DR: A model estimated the components of additive genetic, shared environment, and nonshared environment variances confirming that approximately 40% of the variance remaining in onset age is attributable to genes other than the HD gene and 60% is environmental.
Journal ArticleDOI
The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.
J. Michael Andresen,Javier Gayán,Luc Djoussé,Simone Roberts,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,James F. Gusella,Marcy E. MacDonald,Richard H. Myers,David E. Housman,Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Kelly Posner Gerstenhaber,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Adam M. Brickman,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,John B. Penney,Jang Ho Cha,Micheal Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Anne B. Young,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyoh,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Shelley Peery Moran,Denise Krch,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyer,Michael R. Hayden,E. Almqvist,Ryan R. Brinkman,Oksana Suchowersky,Alexandra Durr,Catherine Dodé,Ferdinando Squitieri,Patrick J. Morrison,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Adam Rosenblatt,Gómez Tortosai Estrella,David Mayo Cabrero,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,J.S. Paulsen,Randi Jones,Andrea Zanko,Tetsuo Ashizawa,Alice Lazzarini,Jian-Liang Li,Jian-Liang Li,Vanessa C. Wheeler,Ana L. Russ,Gang Xu,Jayalakshmi S. Mysore,Tammy Gillis,Michael Hakky,L. Adrienne Cupples,Marie Saint-Hilaire,Steven M. Hersch +96 more
TL;DR: In this article, a two-segment exponential regression model was proposed for age-of-obstinence analysis of the CAG repeat expansion in the HD gene, and a plot of natural log-transformed age of onset against CAG-repeat length revealed this segmental relationship.