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Denise Krch
Researcher at City University of New York
Publications - 7
Citations - 825
Denise Krch is an academic researcher from City University of New York. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 2, co-authored 2 publications receiving 769 citations.
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Journal ArticleDOI
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Javier Gayán,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,J. B. Penney,James F. Gusella,Jang Ho Cha,Michael C. Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Marcy E. MacDonald,Anne B. Young,J. Michael Andresen,David E. Housman,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyo,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Adam M. Brickman,Denise Krch,Shelley Peery,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyeri +57 more
TL;DR: A model estimated the components of additive genetic, shared environment, and nonshared environment variances confirming that approximately 40% of the variance remaining in onset age is attributable to genes other than the HD gene and 60% is environmental.
Journal ArticleDOI
The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.
J. Michael Andresen,Javier Gayán,Luc Djoussé,Simone Roberts,Denise Brocklebank,Stacey S. Cherny,Lon R. Cardon,James F. Gusella,Marcy E. MacDonald,Richard H. Myers,David E. Housman,Nancy S. Wexler,Judith Lorimer,Julie Porter,Fidela Gomez,Carol Moskowitz,Kelly Posner Gerstenhaber,Edith Shackell,Karen Marder,Penchaszadeh Gk,Simone A. Roberts,Adam M. Brickman,Jacqueline Gray,Stephen R. Dlouhy,Sandra Wiktorski,Marion E. Hodes,P. Michael Conneally,John B. Penney,Jang Ho Cha,Micheal Irizarry,Diana Rosas,Steven M. Hersch,Zane R. Hollingsworth,Anne B. Young,Margot de Young,Ernesto Bonilla,Theresa Stillings,Américo Negrette,S. Robert Snodgrass,Maria Dolores Martinez-Jaurrieta,Maria A. Ramos-Arroyoh,Jacqueline Bickham,Juan Sanchez Ramos,Frederick J. Marshall,Ira Shoulson,Gustavo Rey,Andrew Feigin,Norman Arnheim,Amarilis Acevedo-Cruz,Leticia Acosta,Jose Alvir,Kenneth H. Fischbeck,Leslie M. Thompson,Angela Young,Leon S. Dure,Christopher J. O'Brien,Jane S. Paulsen,Shelley Peery Moran,Denise Krch,Penelope Hogarth,Donald S. Higgins,Bernhard Landwehrmeyer,Michael R. Hayden,E. Almqvist,Ryan R. Brinkman,Oksana Suchowersky,Alexandra Durr,Catherine Dodé,Ferdinando Squitieri,Patrick J. Morrison,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Adam Rosenblatt,Gómez Tortosai Estrella,David Mayo Cabrero,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,J.S. Paulsen,Randi Jones,Andrea Zanko,Tetsuo Ashizawa,Alice Lazzarini,Jian-Liang Li,Jian-Liang Li,Vanessa C. Wheeler,Ana L. Russ,Gang Xu,Jayalakshmi S. Mysore,Tammy Gillis,Michael Hakky,L. Adrienne Cupples,Marie Saint-Hilaire,Steven M. Hersch +96 more
TL;DR: In this article, a two-segment exponential regression model was proposed for age-of-obstinence analysis of the CAG repeat expansion in the HD gene, and a plot of natural log-transformed age of onset against CAG-repeat length revealed this segmental relationship.
Journal ArticleDOI
Validation of the Norma Latina neuropsychological assessment battery in individuals with multiple sclerosis in Mexico.
Diego Rivera,Daniela Ramos Usuga,E. Mendoza,Adriana Aguayo Arelis,Brenda Viridiana Rabago Barajas,Miguel Angel Macias Islas,Denise Krch,Anthony Lequerica,Juan Carlos Arango-Lasprilla +8 more
TL;DR: In this article , the authors evaluated the neuropsychological profile of Mexican people with MS and assessed the utility of Norma Latina, a new battery for cognitive assessment in Latin America, in differentiating cognitive test performance between PwMS and healthy controls (HCs).
Posted ContentDOI
Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium
Eamonn Kennedy,Shashank Vadlamani,Hannah M. Lindsey,Pui Wa Lei,Mary Jo-Pugh,Maheen M. Adamson,Martin Alda,Silvia Alonso-Lana,Sonia Ambrogi,Tim J. Anderson,Celso Arango,Robert F. Asarnow,Mihai Avram,Rosa Ayesa-Arriola,Talin Babikian,Nerisa Banaj,Laura Bird,Stefan Borgwardt,Amy Brodtmann,Katharina Brosch,Karen Caeyenberghs,Vince D. Calhoun,Nancy D. Chiaravalloti,David X. Cifu,Benedicto Crespo-Facorro,John C. Dalrymple-Alford,Kristen Dams-O'Connor,Udo Dannlowski,David Darby,Nicholas D. Davenport,John DeLuca,Covadonga M. Díaz-Caneja,Seth G. Disner,Ekaterina Dobryakova,Stefan Ehrlich,Carrie Esopenko,Fabio Ferrarelli,Lea E. Frank,Carol E. Franz,Paola Fuentes-Claramonte,Helen M. Genova,Christopher C. Giza,Janik Goltermann,Dominik Grotegerd,Marius Gruber,Alfonso Gutiérrez-Zotes,Minji Ha,Jan Haavik,Charles H. Hinkin,Kristen R. Hoskinson,Daniela Hubl,Andrei Irimia,Andreas Jansen,Michael Kaess,Xiaojian Kang,Kimbra Kenney,Barbora Kerkova,M. S. Khlif,Minah Kim,Jochen Kindler,Tilo Kircher,Karolína Knížková,Knut K. Kolskår,Denise Krch,William S. Kremen,Taylor Kuhn,Veena Kumari,Jun Soo Kwon,Roberto Langella,Sarah Laskowitz,Jung-ha Lee,Jean Lengenfelder,Spencer W. Liebel,Victoria Liou-Johnson,Sara M. Lippa,Marianne Løvstad,Astri J. Lundervold,Cassandra Marotta,Craig A. Marquardt,P. de Carvalho Mattos,Ahmad Mayeli,Carrie R. McDonald,Susanne Meinert,Tracy R. Melzer,Jessica Merchán-Naranjo,Chantal Michel,Rajendra A. Morey,Benson Mwangi,Daniel J. Myall,Igor Nenadic,Mary R. Newsome,Abraham Nunes,Terence J. O'Brien,Viola Oertel,John M. Ollinger,Alexander Olsen,Victor Ortiz-García de la Foz,Mustafa Ozmen,Heath R. Pardoe,Marise B. Parent,Fabrizio Piras,Federica Piras,Edith Pomarol-Clotet,Jonathan Repple,Geneviève Richard,Jonathan Rodriguez,Mabel Rodriguez,Kelly Rootes-Murdy,Jared A. Rowland,Nicholas P Ryan,Raymond Salvador,Anne-Marthe Sanders,André Schmidt,Jair C. Soares,Gianfranco Spalleta,Filip Spaniel,Alena Stasenko,Frederike Stein,Benjamin Straube,April D. Thames,Florian Thomas-Odenthal,Sophia I. Thomopoulos,Erin B. Tone,Ivan J. Torres,Maya Troyanskaya,Jessica A. Turner,Kristine Moe Ulrichsen,Guillermo E. Umpierrez,Elisabet Vilella,Lucy Vivash,William C. Walker,Emilio Werden,Lars T. Westlye,Krista Wild,Adrian Wroblewski,Mon-Ju Wu,Glenn R. Wylie,Lakshmi N. Yatham,Giovana Zunta-Soares,Paul M. Thompson,David F. Tate,Frank G. Hillary,Emily L. Dennis,Elisabeth A. Wilde +143 more
TL;DR: In this article , the authors focus on the most frequently assessed cognitive domain -memory testing - and demonstrate a process for reliable data harmonization across three common measures, and demonstrate that large-scale data sharing and harmonization initiatives can address reproducibility and integration challenges across the behavioral sciences.
Journal ArticleDOI
Rationale and methodology for examining the acute effects of aerobic exercise combined with varying degrees of virtual reality immersion on cognition in persons with TBI
TL;DR: In this paper , an acute exercise study was conducted to investigate the acute effects of aerobic exercise with incremental degrees of environmental enrichment relative to a control comparison condition on executive function (divided attention and working memory) and processing speed in 24 people with Traumatic Brain Injury.