J
Jacob Raber
Researcher at Oregon Health & Science University
Publications - 253
Citations - 13602
Jacob Raber is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Apolipoprotein E & Water maze. The author has an hindex of 53, co-authored 230 publications receiving 11862 citations. Previous affiliations of Jacob Raber include Scripps Health & University of California, San Francisco.
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Journal ArticleDOI
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
Steven J. Smith,Sylvaine Cases,Dalan R. Jensen,Hubert Chen,Eric Sande,Bryan Tow,David A. Sanan,Jacob Raber,Robert H. Eckel,Robert V. Farese +9 more
TL;DR: It is shown that Dgat-deficient (Dgat−/−) mice are viable and can still synthesize triglycerides, and these mice are lean and resistant to diet-induced obesity.
Journal ArticleDOI
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Radoslaw Rola,Jacob Raber,Angela Rizk,Shinji Otsuka,Scott R. VandenBerg,Duncan R. Morhardt,John R. Fike +6 more
TL;DR: Evidence is provided that irradiation of young animals induces a long-term impairment of dentate subgranular zone neurogenesis that is associated with hippocampal-dependent memory deficits.
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Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis.
Jacob Raber,Radoslaw Rola,Anthony LeFevour,Duncan R. Morhardt,Justine Curley,Shinichiro Mizumatsu,Scott R. VandenBerg,John R. Fike +7 more
TL;DR: It is shown that the Barnes maze is particularly sensitive for the detection of radiation-induced cognitive deficits in young adult mice and the significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation -induced cognitive impairments.
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ApoE genotype accounts for the vast majority of AD risk and AD pathology.
TL;DR: Evidence is provided that apolipoprotein E (apoE) genotype accounts for the majority of Alzheimer's disease (AD) risk and pathology.
Journal ArticleDOI
A role for glia in the progression of Rett's syndrome.
Daniel T. Lioy,Saurabh K. Garg,Saurabh K. Garg,Caitlin E. Monaghan,Caitlin E. Monaghan,Jacob Raber,Jacob Raber,Kevin D. Foust,Brian K. Kaspar,Petra G. Hirrlinger,Frank Kirchhoff,John M. Bissonnette,Nurit Ballas,Gail Mandel,Gail Mandel +14 more
TL;DR: It is shown that glia, like neurons, are integral components of the neuropathology of RTT, and supports the targeting of glia as a strategy for improving the associated symptoms.