J
James Arthos
Researcher at National Institutes of Health
Publications - 141
Citations - 13478
James Arthos is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Antibody. The author has an hindex of 52, co-authored 134 publications receiving 12693 citations. Previous affiliations of James Arthos include Columbia University & Government of the United States of America.
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Journal ArticleDOI
The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection
Elena Martinelli,Filippo Veglia,Diana J. Goode,Natalia Guerra-Perez,Meropi Aravantinou,James Arthos,Michael Piatak,Jeffrey D. Lifson,James F. Blanchard,Agegnehu Gettie,Melissa Robbiani +10 more
TL;DR: The results suggest that animals with higher frequency of CD4+ T cells in circulation and in rectal tissue could be more susceptible to SIV rectal transmission.
Journal ArticleDOI
Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.
Oren J. Cohen,Mauro Vaccarezza,Gordon K. Lam,Barbara F. Baird,Kathryn F. Wildt,Philip M. Murphy,Peter A. Zimmerman,Thomas B. Nutman,Cecil H. Fox,Shelley Hoover,Joseph W. Adelsberger,Michael Baseler,James Arthos,Richard T. Davey,Robin L. Dewar,Julia A. Metcalf,Douglas J. Schwartzentruber,Jan M. Orenstein,Susan Buchbinder,Alfred J. Saah,Roger Detels,John P. Phair,Charles R. Rinaldo,Joseph B. Margolick,Giuseppe Pantaleo,Anthony S. Fauci +25 more
TL;DR: Although epidemiologic data support a role for the mutant CCR5 allele in the determination of the state of long-term nonprogression in some HIV-1- infected individuals, it is not the only determinant, and long- term nonprogressors with the wild-type C CR5 genotype are indistinguishable from heterozygotes from an immunologic and virologic standpoint.
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Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.
Gustavo H. Kijak,Gustavo H. Kijak,Eric Sanders-Buell,Eric Sanders-Buell,Agnès-Laurence Chenine,Agnès-Laurence Chenine,Michael A. Eller,Michael A. Eller,Nilu Goonetilleke,Rasmi Thomas,Rasmi Thomas,Sivan Leviyang,Elizabeth A. Harbolick,Elizabeth A. Harbolick,Meera Bose,Meera Bose,Phuc Pham,Phuc Pham,Celina Oropeza,Celina Oropeza,Kultida Poltavee,Kultida Poltavee,Anne Marie O'Sullivan,Anne Marie O'Sullivan,Erik Billings,Erik Billings,Melanie Merbah,Melanie Merbah,Margaret C. Costanzo,Margaret C. Costanzo,Joanna A. Warren,Bonnie M. Slike,Bonnie M. Slike,Hui Li,Kristina K. Peachman,Kristina K. Peachman,Will Fischer,Feng Gao,Claudia Cicala,James Arthos,Leigh Anne Eller,Leigh Anne Eller,Robert J. O'Connell,Samuel Sinei,Lucas Maganga,Hannah Kibuuka,Sorachai Nitayaphan,Mangala Rao,Mary A. Marovich,Shelly J. Krebs,Shelly J. Krebs,Morgane Rolland,Morgane Rolland,Bette T. Korber,George M. Shaw,Nelson L. Michael,Merlin L. Robb,Merlin L. Robb,Sodsai Tovanabutra,Sodsai Tovanabutra,Jerome H. Kim +60 more
TL;DR: The results demonstrate that early, deep, and frequent sampling is needed to investigate viral/host interaction during AHI, which could help identify prerequisites for prevention and cure of HIV-1 infection.
Journal ArticleDOI
HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis.
Audrey Kinter,Craig A Umscheid,James Arthos,Claudia Cicala,Yin Lin,Robert W. Jackson,Eileen T. Donoghue,Linda A. Ehler,Joseph W. Adelsberger,Ronald L. Rabin,Anthony S. Fauci +10 more
TL;DR: The ability of HIV envelope to induce virus replication in HIV-infected resting CD4+ T cells without triggering apoptosis provides a mechanism for the virus itself to directly participate in the maintenance of HIV production from this cellular reservoir.
Journal ArticleDOI
HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells.
Claudia Cicala,James Arthos,Nina Censoplano,Catherine C. Cruz,Eva Chung,Elena Martinelli,Richard A. Lempicki,Ven Natarajan,Donald VanRyk,Marybeth Daucher,Anthony S. Fauci +10 more
TL;DR: In resting CD4+ T-cells, gp120 activates NFATs and induces their translocation into the nucleus, providing insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs.