J
James Arthos
Researcher at National Institutes of Health
Publications - 141
Citations - 13478
James Arthos is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Antibody. The author has an hindex of 52, co-authored 134 publications receiving 12693 citations. Previous affiliations of James Arthos include Columbia University & Government of the United States of America.
Papers
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Journal ArticleDOI
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
James Arthos,Claudia Cicala,Elena Martinelli,Elena Martinelli,Katilyn Macleod,Donald Van Ryk,Danlan Wei,Zhen Xiao,Timothy D. Veenstra,Thomas P Conrad,Richard A. Lempicki,Sherry McLaughlin,Massimiliano Pascuccio,Ravindra Gopaul,Jonathan P. McNally,Catherine C. Cruz,Nina Censoplano,Eva Chung,Kristin N. Reitano,Shyam Kottilil,Diana J. Goode,Anthony S. Fauci +21 more
TL;DR: It is demonstrated here that the HIV-1 envelope protein gp120 bound to an activated form of α4β7, a peptide motif that mimics structures presented by the natural ligands of α 4β7 in the V2 loop of gp120.
Journal ArticleDOI
Crystal structure of an HIV-binding recombinant fragment of human CD4.
Seong Eon Ryu,Peter D. Kwong,Alemseged Truneh,Terence G. Porter,James Arthos,Martin Rosenberg,Xiaoping Dai,Nguyen Huu Xuong,Richard Axel,Richard Axel,Raymond W. Sweet,Wayne A. Hendrickson,Wayne A. Hendrickson +12 more
TL;DR: The structure of a soluble fragment of CD4 determined at 2.3 Å resolution reveals that the molecule has two intimately associated immunoglobulin-like domains, implicated in HIV recognition by analysis of mutants and antibody binding.
Journal ArticleDOI
Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5
Craig B. Davis,Ivan Dikic,Derya Unutmaz,C. Mark Hill,James Arthos,Michael A. Siani,Darren A. Thompson,Joseph Schlessinger,Dan R. Littman +8 more
TL;DR: The results presented here provide the first evidence for activation of an intracellular signaling event that can initiate multiple signaling pathways as a consequence of contact between HIV-1 and chemokine receptors.
Journal ArticleDOI
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
James B. Munro,Jason Gorman,Xiaochu Ma,Zhou Zhou,James Arthos,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Joel R. Courter,Amos B. Smith,Peter D. Kwong,Scott C. Blanchard,Walther Mothes +12 more
TL;DR: In this paper, fluorophores were introduced into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions.
Journal ArticleDOI
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
Drew Weissman,Ronald L. Rabin,James Arthos,Andrea Rubbert,Mark Dybul,Ruth Swofford,Sundararajan Venkatesan,Joshua M. Farber,Anthony S. Fauci +8 more
TL;DR: It is shown that recombinant envelope proteins from macrophage-tropic HIV and SIV induce a signal through CCR5 on CD4+ T cells and that envelope-mediated signal transduction through C CR5 induces chemotaxis of T cells.