J
James Arthos
Researcher at National Institutes of Health
Publications - 141
Citations - 13478
James Arthos is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Antibody. The author has an hindex of 52, co-authored 134 publications receiving 12693 citations. Previous affiliations of James Arthos include Columbia University & Government of the United States of America.
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Journal ArticleDOI
Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy
Neil Gupta,James Arthos,Prateeti Khazanie,Tavis D. Steenbeke,Nina Censoplano,Eva Chung,Catherine C. Cruz,Margery A. Chaikin,Marybeth Daucher,Shyam Kottilil,Domenico Mavilio,Peter Schuck,Peter D. Sun,Ronald L. Rabin,Sergei Radaev,Donald Van Ryk,Claudia Cicala,Anthony S. Fauci +17 more
TL;DR: A highly polymerized chimeric IgG1/IgA immunoglobulin (Ig) fusion protein is employed that, by virtue of its capacity to extensively crosslink CD16, activates NK cells while directing the lysis of infected target cells.
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Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia.
Shyam Kottilil,Julia O. Jackson,Kristin N. Reitano,Marie A. O'Shea,Gregg Roby,Margaret Lloyd,Jun Yang,Claire W. Hallahan,Catherine Rehm,James Arthos,Richard A. Lempicki,Anthony S. Fauci +11 more
TL;DR: The data demonstrate that ongoing HIV replication results in profound NK-cell abnormalities that are likely to be attributable to the effects of virus-induced immune activation and an increased susceptibility to cell death mediated by CD95-sFasL interactions.
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Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.
Jason Yolitz,Catherine Schwing,Julia Chang,Donald Van Ryk,Fatima Nawaz,Danlan Wei,Claudia Cicala,James Arthos,Anthony S. Fauci +8 more
TL;DR: It is shown that the signal peptide (SP) of HIV Env can impact the glycan profile of gp120, which in turn impacts antigenicity of the mature protein, indicating that the SP is likely subject to antibody-mediated immune pressure.
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The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells.
James Arthos,Claudia Cicala,Sara Selig,Andrew A. White,Hanumanth M. Ravindranath,Donald Van Ryk,Tavis D. Steenbeke,Elizabeth Machado,Prateeti Khazanie,Meredith S. Hanback,Douglas B. Hanback,Ronald L. Rabin,Anthony S. Fauci +12 more
TL;DR: It is concluded that envelope can induce apoptosis in T cells independently of the coreceptor specificity of a given envelope, or the expression profile of CXCR4 or CCR5 on a target cell, but envelope--coreceptor interactions, and in particular, envelope--CX CR4 interactions, can contribute to this process.
Journal ArticleDOI
Structural basis for the interaction between focal adhesion kinase and CD4.
Marie-Line Garron,James Arthos,Jean-François Guichou,Jean-François Guichou,Jonathan P. McNally,Claudia Cicala,Stefan T. Arold +6 more
TL;DR: The results suggest that the FAK-CD4 complex represents an alternative route for eliciting T-cell-specific signals and that it links gp120 engagement to distinctive T- cell signalling during HIV infection.