C
Caitlyn Linde
Researcher at Massachusetts Institute of Technology
Publications - 19
Citations - 2140
Caitlyn Linde is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: CTL* & Epitope. The author has an hindex of 15, co-authored 16 publications receiving 1675 citations. Previous affiliations of Caitlyn Linde include Harvard University.
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Journal ArticleDOI
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.
Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,Tomer Zohar,Tomer Zohar,Matthew D. Slein,John F. Burke,Carolin Loos,Carolin Loos,Denise J. McCulloch,Kira L. Newman,Caitlin R Wolf,Jingyou Yu,Kiel Shuey,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,Aaron G. Schmidt,Todd J. Suscovich,Caitlyn Linde,Yongfei Cai,Dan H. Barouch,Edward T. Ryan,Richelle C. Charles,Douglas A. Lauffenburger,Helen Y. Chu,Galit Alter +27 more
TL;DR: It is demonstrated that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies, point to differences in disease trajectory, highlighting the potential importance of functional antigen- specific humoral immunity to guide patient care and vaccine development.
Journal ArticleDOI
Relative Dominance of Gag p24-Specific Cytotoxic T Lymphocytes Is Associated with Human Immunodeficiency Virus Control
Rosario Zuñiga,Aldo Lucchetti,Patricia Galvan,Shyla Sanchez,Carmen Sánchez,Ana Elena Lambert Hernández,Hugo Sanchez,Nicole Frahm,Caitlyn Linde,Hannah S. Hewitt,William H. Hildebrand,Marcus Altfeld,Todd M. Allen,Bruce D. Walker,Bette T. Korber,Thomas Leitner,Jorge Sanchez,Christian Brander +17 more
TL;DR: Data generated from a Peruvian cohort of untreated, clade B-infected subjects is presented, demonstrating that the proportion of Gag-specific, and in particular p24-reactive, CTL responses among the total virus-specific CTL activity is associated with individuals' CD4 counts and viral loads.
Journal ArticleDOI
Protective Efficacy of Adenovirus/Protein Vaccines Against SIV Challenges in Rhesus Monkeys
Dan H. Barouch,Dan H. Barouch,Galit Alter,Thomas Broge,Caitlyn Linde,Margaret E. Ackerman,Eric P. Brown,Erica N. Borducchi,Kaitlin M. Smith,Joseph P. Nkolola,Jinyan Liu,Jennifer L. Shields,Lily Parenteau,James B. Whitney,Peter Abbink,David Ng’ang’a,Michael S. Seaman,Christy L. Lavine,James R. Perry,Wenjun Li,Arnaud D. Colantonio,Mark G. Lewis,Bing Chen,Holger Wenschuh,Ulf Reimer,Michael Piatak,Jeffrey D. Lifson,Scott A. Handley,Herbert W. Virgin,Marguerite Koutsoukos,Clarisse Lorin,Gerald Voss,Mo Weijtens,Maria G. Pau,Hanneke Schuitemaker +34 more
TL;DR: Rhesus monkeys primed with Ad26 vectors expressing SIVsmE543 Env, Gag, and Pol and boosted with AS01B-adjuvanted Sivmac32H Env gp140 demonstrated complete protection in 50% of vaccinated animals against a series of repeated, heterologous, intrarectal SIVmac251 challenges that infected all controls.
Journal ArticleDOI
Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women.
Ai-ris Y. Collier,Ai-ris Y. Collier,Katherine McMahan,Jingyou Yu,Lisa H. Tostanoski,Ricardo Aguayo,Jessica L Ansel,Abishek Chandrashekar,Shivani A. Patel,Esther A. Bondzie,Daniel Sellers,Julia Barrett,Owen Sanborn,Huahua Wan,Aiquan Chang,Aiquan Chang,Tochi Anioke,Joseph P. Nkolola,Connor Bradshaw,Catherine Jacob-Dolan,Catherine Jacob-Dolan,Jared Feldman,Jared Feldman,Makda S. Gebre,Makda S. Gebre,Erica N. Borducchi,Jinyan Liu,Aaron G. Schmidt,Aaron G. Schmidt,Todd J. Suscovich,Caitlyn Linde,Galit Alter,Galit Alter,Michele R. Hacker,Michele R. Hacker,Dan H. Barouch +35 more
TL;DR: In this article, the authors evaluated the immunogenicity of COVID-19 mRNA vaccines in pregnant and lactating women, including against emerging SARS-CoV-2 variants of concern.
Journal ArticleDOI
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nicole Frahm,Photini Kiepiela,Sharon Adams,Caitlyn Linde,Hannah S. Hewitt,Kaori Sango,Margaret E. Feeney,Marylyn M. Addo,Mathias Lichterfeld,Matthew P. Lahaie,Eunice Pae,Alysse G. Wurcel,Alysse G. Wurcel,Timothy Roach,M. Anne St. John,Marcus Altfeld,Francesco M. Marincola,Corey Moore,Simon Mallal,Mary Carrington,David Heckerman,Todd M. Allen,James I. Mullins,Bette T. Korber,Bette T. Korber,Philip J. R. Goulder,Philip J. R. Goulder,Bruce D. Walker,Bruce D. Walker,Christian Brander +29 more
TL;DR: Analysis of cytotoxic T lymphocyte responses restricted by HLA-B*1503 suggests that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination ofSubdominant yet effective epitopes from circulating viral populations.