J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
Papers
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Journal ArticleDOI
FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue
Yingyi Zhang,Jielu Hao,Mariana G. Tarragó,Gina M. Warner,Nino Giorgadze,Qing Wei,Yan Huang,Kai He,Chuan Chen,Thais Peclat,Thomas A. White,Kun Ling,Tamar Tchkonia,James L. Kirkland,Eduardo N. Chini,Jinghua Hu +15 more
TL;DR: It is discovered that obese Fbf1tm1a/tm 1a mice develop severe obesity, but surprisingly, are not predisposed to adverse metabolic complications and are protected from diabetes and premature death.
Patent
Human adipocyte cell populations and methods for identifying modulators of same
TL;DR: In this article, the authors present methods of obtaining high-yield, essentially pure human predipocyte cultures, which are then used for identifying adipogenic modulatory agents, e.g., high-throughput screening assays.
Book ChapterDOI
Inhibitors of preadipocyte replication: opportunities for the treatment of obesity.
TL;DR: Although the amount of fat tissue can increase or decrease more rapidly and to a greater extent than most other tissues, appetite suppression, dietary restriction, or surgical methods for reducing caloric intake can result in loss not only of fat mass, but also of muscle and other components of lean body mass.
Journal ArticleDOI
Do Geriatric Programs Decrease Long-Term Use of Acute Care Beds?
Christopher D. Brymer,Catherine A. Kohm,Gary Naglie,Lorie Shekter‐Wolfson,Marissa L. Zorzitto,Keith O'Rourke,James L. Kirkland +6 more
TL;DR: Whether the introduction of coordinated geriatric and discharge planning services at teaching and community hospitals in Toronto has changed the number of beds occupied by patients awaiting transfer to long‐term care institutions is investigated.
Journal ArticleDOI
Mechanisms of vascular dysfunction in the interleukin-10-deficient murine model of preeclampsia indicate nitric oxide dysregulation
Hajrunisa Cubro,Karl A. Nath,Sonja Suvakov,Oscar Garcia-Valencia,Santosh Parashuram,Wendy M. White,Wendy M. White,Tracey L. Weissgerber,Tracey L. Weissgerber,Meryl C. Nath,Natasa Milic,Natasa Milic,Fernando Sontag,Livius V. d’Uscio,Yi Zhu,James L. Kirkland,Tamar Tchkonia,Mariam P. Alexander,Reade A. Quinton,Zvonimir S. Katusic,Joseph P. Grande,Vesna D. Garovic +21 more
TL;DR: The results identify the role of IL- 10 deficiency in dysregulation of the cyclooxygenase pathway and vascular dysfunction in the IL-10-/-sPE murine model of preeclampsia, and point towards a possible contribution of nitric oxide dysregulation.