J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
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Journal ArticleDOI
New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms.
TL;DR: Interventions targeting many fundamental aging processes are being developed, including dietary manipulations, metformin, mTOR (mechanistic target of rapamycin) inhibitors, and senolytics, which could lead to greater healthspan benefits than treating age-related diseases one at a time.
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Translating the Science of Aging into Therapeutic Interventions
TL;DR: Life and health span have been extended in experimental animals using drugs that are potentially translatable into humans and strategies for developing a path from the bench to the bedside are reviewed for interventions that target fundamental aging mechanisms.
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Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction.
TL;DR: Targeting senescent cells could be a promising way to improve healthspan in aged population because inhibition of the JAK pathway suppresses the SASP in senescence-associated secretory phenotype and alleviates age-related tissue dysfunction.
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Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
Sonja Suvakov,Hajrunisa Cubro,Wendy M. White,Yvonne S. Butler Tobah,Tracey L. Weissgerber,Kyra L. Jordan,Xiang Y. Zhu,John R. Woollard,Fouad T. Chebib,Natasa Milic,Natasa Milic,Joseph P. Grande,Ming Xu,Tamara Tchkonia,James L. Kirkland,Lilach O. Lerman,Vesna D. Garovic +16 more
TL;DR: The data suggest that MSC senescence exerts inhibitory effects on angiogenesis in preeclampsia andSenolytic agents may offer the opportunity for mechanism-based therapies.
Journal ArticleDOI
Hyperoxia-induced cellular senescence in fetal airway smooth muscle cells
Pavan Parikh,R.D. Britt,L. Manlove,Sarah A. Wicher,A.M. Roesler,Jovanka Ravix,Jacob J. Teske,Michael A. Thompson,Gary C. Sieck,James L. Kirkland,Nathan K. LeBrasseur,Daniel J. Tschumperlin,Christina M. Pabelick,Y. S. Prakash +13 more
TL;DR: The data show that induction of cellular senescence by hyperoxia leads to secretion of inflammatory factors and has a functional effect on naïve ASM, which may contribute to pediatric airway disease in the context of sequelae due to preterm birth.