J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
Papers
More filters
Journal ArticleDOI
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Joshua N. Farr,Dominik Saul,Madison L. Doolittle,J. Kaur,Jennifer L. Rowsey,Stephanie J Vos,Mitchell N Froemming,Anthony B. Lagnado,Yi Zhu,Megan M. Weivoda,Yuji Ikeno,Robert J. Pignolo,Laura J. Niedernhofer,Paul D. Robbins,Diana Jurk,João F. Passos,Nathan K. LeBrasseur,Tamara Tchkonia,James L. Kirkland,David G. Monroe,Sundeep Khosla +20 more
TL;DR: In this article , the effects of local versus systemic senolysis during aging using bone as a prototype tissue were investigated in a mouse model (p16-LOX-ATTAC) that allows for inducible SnC elimination (senolysis) in a cell-specific manner.
Posted ContentDOI
Length-independent telomere damage drives cardiomyocyte senescence
Rhys Anderson,Anthony B. Lagnado,Damien Maggiorani,Anna Walaszczyk,Emily Dookun,James Chapman,Jodie Birch,Hanna Salmonowicz,Mikolaj Ogrodnik,Diana Jurk,Carole J. Proctor,Clara Correia-Melo,Stella Victorelli,Edward Fielder,Rolando Berlinguer-Palmini,A Owens,Laura C. Greaves,Kathy L Kolsky,Angelo Parini,Douin-Echinard,Nathan K. LeBrasseur,Helen M. Arthur,Simon Tual-Chalot,Marissa J. Schafer,Carolyn M Roos,Jordan D. Miller,Neil Robertson,Jelena Mann,Peter D. Adams,Tamara Tchkonia,James L. Kirkland,Jeanne Mialet-Perez,Gavin D. Richardson,João F. Passos +33 more
TL;DR: Physiological or genetic clearance of senescent cells in mice alleviates myocardial hypertrophy and fibrosis, detrimental features of cardiac ageing, and promotes cardiomyocyte regeneration and the mechanism by which senescence can occur and contribute to ageing in post-mitotic tissues is described.
Journal ArticleDOI
A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating predipocytes
TL;DR: To understand the role of free fatty acid (FFA) incorporation in the accumulation of lipids in the adipocyte and ultimately in the development of obesity, 13C nuclear magnetic resonance was used to study lipid metabolism in differentiating preadipocytes.
Posted ContentDOI
Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimer’s mouse model
Andrea Stojakovic,Sergey Trushin,Anthony Sheu,Layla Khalili,Su-Youne Chang,Xing Li,Trace A. Christensen,Jeffrey L. Salisbury,Rachel E. Geroux,Benjamin Gateno,Padraig J. Flannery,Mrunal Dehankar,Cory C. Funk,Jordan Wilkins,Anna Stepanova,Tara O’Hagan,Alexander Galkin,Jarred J. Nesbitt,Xiujuan Zhu,Utkarsh Tripathi,Slobodan Macura,Tamar Tchkonia,Tamar Pirtskhalava,James L. Kirkland,Rachel A. Kudgus,Renee A. Schoon,Joel M. Reid,Yu Yamazaki,Takahisa Kanekiyo,Song Zhang,Emirhan Nemutlu,Petras P. Dzeja,Adam Jaspersen,Christopher Ye In Kwon,Michael K. Lee,Eugenia Trushina +35 more
TL;DR: It is demonstrated that mitochondrial respiratory chain complex I is an important small molecule druggable target in Alzheimer’s Disease (AD) and pathways improved by the treatment in APP/PS1 mice, including the immune system response and neurotransmission, represent mechanisms essential for therapeutic efficacy in AD patients.