J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
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Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cells
Remi-Martin Laberge,Judith Campisi,Albert R. Davalos,Marco Demaria,Nathaniel David,Alain Philippe Vasserot,James L. Kirkland,Tamar Tchkonia,Yi Zhu,Jennifer H. Elisseeff,Chaekyu Kim,Ok-Hee Jeon +11 more
Journal ArticleDOI
Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology
Anne B. Newman,Stephen B. Kritchevsky,Jack M. Guralnik,Steven R. Cummings,Marcel E. Salive,George A. Kuchel,Jennifer A. Schrack,Martha Clare Morris,David R. Weir,Andrea A. Baccarelli,Joanne M. Murabito,Yoav Ben-Shlomo,Yoav Ben-Shlomo,Mark A. Espeland,James L. Kirkland,David Melzer,David Melzer,Luigi Ferrucci +17 more
TL;DR: Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.
Journal ArticleDOI
Targeting cellular senescence in metabolic disease
TL;DR: Senescence-targeting therapeutics, including senolytic drugs and strategies to increase immune clearance of senescent cells, hold significant promise for treating metabolic dysfunction in multiple tissues and disease states as discussed by the authors .
Journal ArticleDOI
Incorporation of [1‐13C]oleate into cellular triglycerides in differentiating 3T3L1 cells
TL;DR: The quantity of oleate incorporated into TG was found to increase as preadipocytes differentiated into fat cells, and the ratio of unesterified [1-13C]oleate to total stored fatty acids was higher in less differentiated Cells, and declined at later stages of differentiation as cells accumulated fatty acids through de novo synthesis.
Journal ArticleDOI
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
Ritesh K. Baboota,Aidin Rawshani,Laurianne Bonnet,Xiangyu Li,Hong Yang,Adil Mardinoglu,Tamara Tchkonia,James L. Kirkland,Anne Hoffmann,Arne Dietrich,Jeremie Boucher,Matthias Blüher,Ulf Smith +12 more
TL;DR: In this article , the role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and non-altaltic steatohepatitis (NASH) is not well understood.