James L. Kirkland

TL;DR: In this article, the authors provide methods for screening potential therapeutic compounds useful in the treatment of metabolic diseases, e.g., diabetes. In particular, the invention provides methods of identifying compounds which modulate the activity of a mitochondrial anion carrier (MAC) which include contacting assay vesicles of the present invention with test compounds, determining the ability of the test compounds to modulating the transport of a MAC substrate across the lipid bilayer of the vesicle, and identifying the test compound as a modulator of MAC activity.

TL;DR: In this paper, the authors found that the hyperglycemic and uremic milieu may diminish regenerative capacity of patient-derived MSC paracrine function in experimental diabetic kidney disease.

TL;DR: The field of geroscience has made remarkable advancements in understanding the mechanisms underlying biological aging and identified ways to target aging pathways using both novel agents and repurposed therapies.

TL;DR: In this article, a preadipocyte strain that maintains replicative potential and adipogenic capacity was described, and used as research tools, in screening assays, and as therapeutic and/or clinical reagents.

TL;DR: This study aimed at investigating the temporal expression and phosphorylation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in muscle wasting associated with the ICU condition to characterize the JAK/ STAT proteins and the related changes leading or responding to their activation during exposure to theICU condition.