J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
Papers
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Journal ArticleDOI
Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.
Mandeep Singh,Michael D. Jensen,Amir Lerman,Sudhir S. Kushwaha,Charanjit S. Rihal,Bernard J. Gersh,Atta Behfar,Tamara Tchkonia,Randal J. Thomas,Ryan J. Lennon,L R Keenan,A G Moore,James L. Kirkland +12 more
TL;DR: The safety and feasibility of low-dose rapamycin and its effect on SASP and frailty in elderly undergoing cardiac rehabilitation (CR) is studied and some correlation between some senescence markers and physical performance is observed.
Book ChapterDOI
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases.
Erin O. Wissler Gerdes,Yi Zhu,B. Melanie Weigand,Utkarsh Tripathi,Terence C. Burns,Tamar Tchkonia,James L. Kirkland +6 more
TL;DR: Roles of senescent cells in neurodegenerative diseases and potential implications of senolytic agents as an innovative treatment are considered and agents that selectively target these cells are targeted in preclinical models are considered.
Journal ArticleDOI
Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate
TL;DR: In this paper, the authors evaluated the influence of octanoate and oleate on metabolism in fat cells and found that octanoates were esterified to a greater extent at the sn-1,3 position of glyceryl carbons than at the n-2 position.
Journal ArticleDOI
Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.
Marcelo Borges Cavalcante,Marcelo Borges Cavalcante,Tatiana D. Saccon,Tatiana D. Saccon,Allancer D. C. Nunes,James L. Kirkland,Tamara Tchkonia,Augusto Schneider,Michal M. Masternak +8 more
TL;DR: A role for the Pi3k/Akt1/mTor signaling pathway in uterine aging is demonstrated and a possible anti-fibrotic effect in the uterus of D+Q senolytic therapy is suggested for the first time.
Journal ArticleDOI
Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience.
Derek M. Huffman,Jamie N. Justice,Michael B. Stout,James L. Kirkland,Nir Barzilai,Steven N. Austad +5 more
TL;DR: The Network discussed challenges in modeling age-related human chronic diseases and concluded that more attention needs to be paid to developing disease models with later age of onset, models of co- and multimorbidity, diversifying the strains and sexes commonly used in aging research, and considering additional species.