J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
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Animal models for cancer and uses thereof
Judith Campisi,Judith Campisi,Jan M. van Deursen,James L. Kirkland,Tamar Tchkonia,Darren J. Baker,Marco Demaria +6 more
TL;DR: In this article, non-human animal cancer models are provided for identifying and characterizing agents useful for therapy and prophylaxis of cancers, including drugs useful for diminishing side effects related to cancer therapies and reducing metastatic disease.
Journal ArticleDOI
JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R.
Alex B. Addinsall,Nicola Cacciani,Hazem Akkad,Heba Salah,Heba Salah,Tamara Tchkonia,James L. Kirkland,Lars Larsson +7 more
TL;DR: In this paper, the potential of JAK1/2 inhibition was assessed in an experimental model of critical illness myopathy, where soleus muscle size and force are impaired, and it was shown that JAK/STAT inhibition improves soleus function by modulating the complement cascade and muscle monocyte infiltration.
Journal ArticleDOI
Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
Evan C. Hadley,George A. Kuchel,Anne B. Newman,Heather G. Allore,Jenna M. Bartley,Cindy S. Bergeman,Michael L. Blinov,Cathleen S. Colón-Emeric,Cathleen S. Colón-Emeric,Firdaus S Dabhar,Laura L. Dugan,Chhanda Dutta,Basil A. Eldadah,Luigi Ferrucci,James L. Kirkland,Stephen B. Kritchevsky,Lewis A. Lipsitz,Neelesh K. Nadkarni,May J. Reed,Kenneth E. Schmader,Kenneth E. Schmader,Felipe Sierra,Stephanie A. Studenski,Ravi Varadhan,Jeremy D. Walston,Heather E. Whitson,Heather E. Whitson,Raymond Yung +27 more
Antidiabetic Effects of the Senolytic Agent Dasatinib.
Omid Salaami,Chia-Ling Kuo,Matthew T. Drake,George A. Kuchel,James L. Kirkland,Robert J. Pignolo +5 more
TL;DR: In this paper, the authors evaluated the antidiabetic effects of the senolytic agent dasatinib in older patients with type 2 diabetes mellitus and found that the relative difference in weight accounts for 8.4 mg of the 43.7 mg/dL blood glucose value decrease, or 19.2%.
Journal ArticleDOI
Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate
TL;DR: In this article , the effects of palmitic acid (PA) on human subcutaneous and omental adipocytes were investigated in vitro, showing that PA induced DNA damage and increased p16INK4a levels.