James L. Kirkland

TL;DR: Circulating activin A is increased in human DKD and correlates with reduced kidney function and kidney injury markers, which underscore the role of inflammation and provide a basis for further exploration ofactivin A as a diagnostic marker and therapeutic target in DKD.

TL;DR: In this paper, the authors describe a National Institutes of Health-funded, multicenter, placebo-controlled clinical trial of Fisetin for older adult skilled nursing facility (SNF) residents who have been, or become, SARS-CoV-2 rtPCR positive, including the rationale for targeting fundamental aging mechanisms in such patients.

TL;DR: In this paper, isotope labeling methods were used to examine proteostatic mechanisms in older male mice and found that 17α-E2 had no effect on protein synthesis or DNA synthesis in multiple tissues including white adipose tissue.

TL;DR: In this article, the authors used unbiased single-cell RNA-sequencing to identify stenotic-kidney epithelial cells undergoing both mesenchymal transition and senescence.

TL;DR: Although weight accumulation in response to HFD was similar between Tac1(-/-) mice and wild-type littermates, Tac1-deficient mice demonstrated lower glucose and leptin and increased adiponectin blood levels and showed improved responses to insulin challenge after HFD, demonstrating an important role for SP in adipose tissue responses and obesity-associated pathologies.