J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
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Journal ArticleDOI
Glomerular dysfunction in the aging Fischer 344 rat is associated with excessive growth and normal mesangial cell function.
Gerard F. McDermott,Alistair J. Ingram,James W. Scholey,James L. Kirkland,Catharine I. Whiteside +4 more
TL;DR: In the Fischer 344 rat, mesangial cell Ca2+ signaling, contraction, and proliferation responsiveness are unchanged with aging, and Continued growth is associated with the glomerulosclerosis of aging.
Journal ArticleDOI
Two preadipocyte subtypes cloned from human omental fat.
TL;DR: It is proposed that preadipocytes of the rapidly replicating and the slowly replicating subtypes may be at different stages along the pathway between uncommitted precursor cells and differentiated adipocytes.
Journal ArticleDOI
Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.
Joshua N. Farr,Ming Xu,Megan M. Weivoda,David G. Monroe,Daniel G. Fraser,Jennifer L Onken,Brittany A Negley,Jad G Sfeir,Mikolaj Ogrodnik,Christine M Hachfeld,Nathan K. LeBrasseur,Matthew T. Drake,Robert J. Pignolo,Tamar Pirtskhalava,Tamara Tchkonia,Merry Jo Oursler,James L. Kirkland,Sundeep Khosla +17 more
TL;DR: This corrects the article DOI: 10.1038/nm.4385 to indicate that the number of protons in the nucleus is four, not five, as previously reported.
Journal ArticleDOI
Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies
Sonja Suvakov,Ranine Ghamrawi,Hajrunisa Cubro,Haitao Tu,Haitao Tu,Wendy M. White,Yvonne S. Butler Tobah,Natasa Milic,Natasa Milic,Joseph P. Grande,Julie M. Cunningham,Fouad T. Chebib,Larissa G.P. Langhi Prata,Yi Zhu,Tamara Tchkonia,James L. Kirkland,Karl A. Nath,Aleksandar Milosavljevic,Vesna D. Garovic +18 more
TL;DR: In this article, the authors showed that preeclamptic women undergo accelerated epigenetic ageing during pregnancy and exhibit higher levels/expression of senescence-associated secretory phenotype factors in blood and adipose tissue.
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Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes.
Wen Guo,Yahui Li,Wentao Liang,Siu Wong,Caroline M. Apovian,James L. Kirkland,Barbara E. Corkey +6 more
TL;DR: It is demonstrated that preadipocyte differentiation could be regulated by extracellular BME, and basal and TNFalpha-induced NFkappaB activity and increased basal and ciglitazone-induced PPARgamma activity may contribute to the pro-adipogenic effect of BME in differentiating F442APreadipocytes.