J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
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Journal ArticleDOI
Aging, Depot Origin, and Preadipocyte Gene Expression
Mark Cartwright,Karen Schlauch,Karen Schlauch,Mark E. Lenburg,Tamara Tchkonia,Tamar Pirtskhalava,Andrew Cartwright,Thomas Thomou,James L. Kirkland +8 more
TL;DR: Age-related changes in preadipocyte gene expression differ among depots, potentially contributing to fat redistribution and dysfunction, as occurs in fat tissue.
Journal ArticleDOI
Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer
Kirsten K. Ness,James L. Kirkland,Maria M. Gramatges,Zhaoming Wang,Mondira Kundu,Kelly McCastlain,Xiujie Li-Harms,Jinghui Zhang,Tamar Tchkonia,Saskia M. F. Pluijm,Gregory T. Armstrong +10 more
TL;DR: There is now a critical need for research to elucidate the biologic mechanisms of premature aging in survivors of childhood cancer, which could pave the way for new frontiers in the prevention of these life-changing outcomes.
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Trail Receptor Deletion in Mice Suppresses the Inflammation of Nutrient Excess
Leila Idrissova,Harmeet Malhi,Nathan W. Werneburg,Nathan K. LeBrasseur,Steven F. Bronk,Christian D. Fingas,Tamar Tchkonia,Tamar Pirtskhalava,Thomas A. White,Michael B. Stout,Petra Hirsova,Anuradha Krishnan,Christian Liedtke,Christian Trautwein,Niklas Finnberg,Wafik S. El-Deiry,James L. Kirkland,Gregory J. Gores +17 more
TL;DR: These data advance the concept that macrophage-associated hepatic and adipose tissue inflammation of nutrient excess requires TR signaling, and reduce chemotaxis and diminished activation of nuclear factor-κ B signaling upon activation by palmitate and lipopolysaccharide.
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A systems biology approach to the effect of aging, immunosenescence and vaccine response.
Gregory A. Poland,Inna G. Ovsyannikova,Richard B. Kennedy,Nathaniel D. Lambert,James L. Kirkland +4 more
TL;DR: How the application of systems biology can advance the understanding of vaccine immunosenescence with a view toward how such information could lead to strategies to overcome the lower immunogenicity of vaccines in the elderly is covered.
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Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice.
Tatiana D. Saccon,Tatiana D. Saccon,Ravinder Nagpal,Hariom Yadav,Marcelo Borges Cavalcante,Allancer D. C. Nunes,Augusto Schneider,Adam Gesing,Brian L. Hughes,Matthew J. Yousefzadeh,Tamar Tchkonia,James L. Kirkland,Laura J. Niedernhofer,Paul D. Robbins,Michal M. Masternak,Michal M. Masternak +15 more
TL;DR: In this paper, the effect of Dasatinib plus quercetin (D+Q) on senescence (p16Ink4a and p21Cip1) and inflammation (Cxcl1, Il1β, Il6, Mcp1, and Tnfα) markers in small (ileum) and large (caecum and colon) intestine in aged mice compared to age-matched placebo-treated mice (n = 10).