J
James L. Kirkland
Researcher at Mayo Clinic
Publications - 322
Citations - 33834
James L. Kirkland is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Adipose tissue. The author has an hindex of 76, co-authored 280 publications receiving 23328 citations. Previous affiliations of James L. Kirkland include Buck Institute for Research on Aging & University of Pittsburgh.
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Journal ArticleDOI
Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
Laure-Emmanuelle Zaragosi,Brigitte Wdziekonski,Phi Villageois,Mayoura Keophiphath,Marie Maumus,Tamara Tchkonia,Virginie Bourlier,Tala Mohsen-Kanson,Annie Ladoux,Christian Elabd,Marcel Scheideler,Zlatko Trajanoski,Yasuhiro Takashima,Ez-Zoubir Amri,Danièle Lacasa,Coralie Sengenès,Gérard Ailhaud,Karine Clément,Anne Bouloumié,James L. Kirkland,Christian Dani +20 more
TL;DR: A model in which macrophages that are located in adipose tissue regulate adipose progenitor self-renewal through activin A is proposed, which plays a significant role in human adipogenesis.
Journal ArticleDOI
Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes.
Vandana Gupta,Shalender Bhasin,Wen Guo,Rajan Singh,Rika Miki,Pratibha Chauhan,Karen Choong,Tamara Tchkonia,Nathan K. LeBrasseur,John N. Flanagan,James A. Hamilton,Jason Viereck,Navjot S. Narula,James L. Kirkland,Ravi Jasuja,Ravi Jasuja +15 more
TL;DR: DHT inhibits adipogenic differentiation of h MSCs and human preadipocytes through an AR-mediated pathway, but it does not affect the proliferation of either hMSCs or preadendipocytes.
Journal ArticleDOI
Cellular senescence: at the nexus between ageing and diabetes
TL;DR: The current data on cellular senescence in key target tissues associated with the development and clinical phenotypes of type 2 diabetes are summarized and the therapeutic potential of targeting senescent cells in diabetes is discussed.
Journal ArticleDOI
Senolytics reduce coronavirus-related mortality in old mice.
Christina D. Camell,Matthew J. Yousefzadeh,Yi Zhu,Larissa G.P. Langhi Prata,Matthew A. Huggins,Mark Pierson,Lei Zhang,Ryan D. O’Kelly,Tamar Pirtskhalava,Pengcheng Xun,Keisuke Ejima,Ailing Xue,Utkarsh Tripathi,Jair Machado Espindola-Netto,Nino Giorgadze,Elizabeth J. Atkinson,Christina L. Inman,Kurt O. Johnson,Stephanie H. Cholensky,Timothy W. Carlson,Nathan K. LeBrasseur,Sundeep Khosla,M. Gerard O'Sullivan,David B. Allison,Stephen C. Jameson,Alexander Meves,Ming Li,Y. S. Prakash,Sergio E. Chiarella,Sara E. Hamilton,Tamara Tchkonia,Laura J. Niedernhofer,James L. Kirkland,Paul D. Robbins +33 more
TL;DR: In this paper, the authors demonstrate that senescent cells become hyper-inflammatory in response to pathogen-associated molecular patterns (PAMPs), including SARS-CoV-2 spike protein-1, increasing expression of viral entry proteins and reducing antiviral gene expression in non-SnCs through a paracrine mechanism.
Journal ArticleDOI
Frailty in childhood cancer survivors.
Kirsten K. Ness,Gregory T. Armstrong,Mondira Kundu,Carmen L. Wilson,Tamara Tchkonia,James L. Kirkland +5 more
TL;DR: Mounting evidence suggests that poor fitness, muscular weakness, and cognitive decline are common among adults treated for childhood malignancies, and that risk factors for these outcomes are not limited to those treated with cranial radiation.