J
Jan-Peter Sperhake
Researcher at University of Hamburg
Publications - 68
Citations - 2970
Jan-Peter Sperhake is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Autopsy. The author has an hindex of 13, co-authored 58 publications receiving 1924 citations. Previous affiliations of Jan-Peter Sperhake include American Board of Legal Medicine.
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Journal ArticleDOI
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.
Dominic Wichmann,Jan-Peter Sperhake,Marc Lütgehetmann,Stefan Steurer,Carolin Edler,Axel Heinemann,Fabian Heinrich,Herbert Mushumba,Inga Kniep,Ann Sophie Schröder,Christoph Burdelski,Geraldine de Heer,Axel Nierhaus,Daniel Frings,Susanne Pfefferle,Heinrich Becker,Hanns Bredereke-Wiedling,Andreas de Weerth,Hans-Richard Paschen,Sara Sheikhzadeh-Eggers,Axel Stang,Stefan Schmiedel,Carsten Bokemeyer,Marylyn M. Addo,Martin Aepfelbacher,Klaus Püschel,Stefan Kluge +26 more
TL;DR: In this paper, the causes of COVID-19-related deaths were investigated in a single academic medical center in the German federal state of Hamburg for patients dying with a polymerase chain reaction-confirmed diagnosis of CoV-19 patients.
Journal ArticleDOI
Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany.
Carolin Edler,Ann Sophie Schröder,Martin Aepfelbacher,Antonia Fitzek,Axel Heinemann,Fabian Heinrich,Anke Klein,Felicia Langenwalder,Marc Lütgehetmann,Kira Meißner,Klaus Püschel,Julia Schädler,Stefan Steurer,Herbert Mushumba,Jan-Peter Sperhake +14 more
TL;DR: This study provides the largest overview of autopsies of SARS-CoV-2-infected patients presented so far and proposes a proposal for the categorisation of deaths with Sars-Cov-2 infection.
Journal ArticleDOI
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.
Yu Zhao,Christoph Kilian,Jan-Eric Turner,Lidia Bosurgi,Lidia Bosurgi,Kevin Roedl,Patricia Bartsch,Ann-Christin Gnirck,Filippo Cortesi,Christoph Schultheiß,Malte Hellmig,Leon U. B. Enk,Fabian Hausmann,Alina Borchers,Milagros N. Wong,Hans-Joachim Paust,Francesco Siracusa,Nicola Scheibel,Marissa Herrmann,Elisa Rosati,Petra Bacher,Dominik Kylies,Dominik Jarczak,Marc Lütgehetmann,Susanne Pfefferle,Stefan Steurer,Julian Schulze Zur-Wiesch,Victor G. Puelles,Jan-Peter Sperhake,Marylyn M. Addo,Ansgar W. Lohse,Mascha Binder,Samuel Huber,Tobias B. Huber,Stefan Kluge,Stefan Bonn,Ulf Panzer,Nicola Gagliani,Christian Krebs +38 more
TL;DR: In this article, the role of the lung-specific immune response was investigated by profiling immune cells in bronchoalveolar lavage fluid and blood collected from COVID-19 patients with severe disease and bacterial pneumonia patients not associated with viral infection.
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The Blood-Brain Barrier is Dysregulated in COVID-19 and Serves as a CNS Entry Route for SARS-CoV-2
Susanne Krasemann,Undine Haferkamp,Susanne Pfefferle,Marcel S Woo,Fabian Heinrich,Michaela Schweizer,A Appelt-Menzel,Barenberg J,Jennifer Leu,Kristin Hartmann,Edda Thies,Littau Jl,Diego Sepulveda-Falla,L. Zhang,Ton K,Liang Y,Jakob Matschke,Franz Ricklefs,Thomas Sauvigny,Jan-Peter Sperhake,Antonia Fitzek,Gerhartl A,Brachner A,Sören Franzenburg,Andre Franke,Moese S,Müller F,Geisslinger G,Carsten Claussen,Kannt A,Andrea Zaliani,P. Gribbon,Benjamin Ondruschka,Winfried Neuhaus,Manuel A. Friese,Markus Glatzel,Ole Pless +36 more
TL;DR: It is reported that the blood-brain barrier (BBB) and its microenvironment show pronounced upregulation of interferon signaling pathways in fatal COVID-19, providing direct evidence for SARS-CoV-2 brain entry across the BBB resulting in an increase in interferons signaling.
Journal ArticleDOI
Molecular consequences of SARS-CoV-2 liver tropism
Nicola Wanner,Geoffroy Andrieux,Pau Badia-i-Mompel,Carolin Edler,Susanne Pfefferle,Maja T. Lindenmeyer,Christian Schmidt-Lauber,Jan Czogalla,Milagros N. Wong,Yusuke Okabayashi,Fabian Braun,Marc Lütgehetmann,Elisabeth Meister,Shun Lu,Maria de las Mercedes Noriega,Thomas Günther,Adam Grundhoff,Nicole Fischer,Hanna Bräuninger,Diana Lindner,Dirk Westermann,Fabian Haas,Kevin Roedl,Stefan Kluge,Marylyn M. Addo,Samuel Huber,Ansgar W. Lohse,Jochen Reiser,Benjamin Ondruschka,Jan-Peter Sperhake,Julio Saez-Rodriguez,Melanie Boerries,Salim S. Hayek,Martin Aepfelbacher,Pietro Scaturro,Victor G. Puelles,Tobias B. Huber +36 more
TL;DR: In this article , the authors provide clinical, histopathological, molecular and bioinformatic evidence for the hepatic tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showing tropism towards several organs, including the heart and kidney.