J
Janet Markland
Researcher at University of Saskatchewan
Publications - 20
Citations - 1516
Janet Markland is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Population & Rheumatoid factor. The author has an hindex of 15, co-authored 20 publications receiving 1373 citations.
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Journal ArticleDOI
A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma
Janet E. Pope,Nicholas Bellamy,James R. Seibold,Murray Baron,Michael H. Ellman,Simon Carette,C. Douglas Smith,Ian M. Chalmers,Paul Hong,David P. O'Hanlon,Elzbieta Kaminska,Janet Markland,J Sibley,Luis J. Catoggio,Daniel E. Furst +14 more
TL;DR: Although results of this trial demonstrated a trend in favor of MTX versus placebo in the treatment of early diffuse SSc, the between-group differences were small and the power to rule out false-negative results was only 50%.
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Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives
Carol A. Hitchon,Fatiha Chandad,Elizabeth D. Ferucci,Annemiek Willemze,Andreea Ioan-Facsinay,Diane van der Woude,Janet Markland,David Robinson,Brenda Elias,Marianna M. Newkirk,René E. M. Toes,Tom W J Huizinga,Hani El-Gabalawy +12 more
TL;DR: In a genetically predisposed population of NAN patients with RA and their relatives, anti-P.
Journal ArticleDOI
Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease.
Andreea Ioan-Facsinay,Annemiek Willemze,David B. Robinson,Christine A. Peschken,Janet Markland,Diane van der Woude,Brenda Elias,Henri A. Ménard,Marianna M. Newkirk,Marvin J. Fritzler,René E. M. Toes,Tom W J Huizinga,Hani El-Gabalawy +12 more
TL;DR: The fine specificity and isotype usage of the ACPA response are qualitatively different in health and disease, and Epitope spreading and expansion of the isotype repertoire might be necessary for development of RA, and this could be facilitated by the presence of RF antibodies.
Journal ArticleDOI
Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis
Maureen D. Mayes,Lara Bossini-Castillo,Olga Y. Gorlova,Jose Ezequiel Martin,Xiaodong Zhou,Wei V. Chen,Shervin Assassi,Jun Ying,Filemon K. Tan,Frank C. Arnett,John D. Reveille,Sandra G. Guerra,María Teruel,F.D. Carmona,Peter K. Gregersen,Annette Lee,Elena López-Isac,Eguzkine Ochoa,Patricia Carreira,Carmen P. Simeon,Ivan Castellví,Miguel A. González-Gay,Alexandra Zhernakova,Leonid Padyukov,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Cisca Wijmenga,Matthew A. Brown,Lorenzo Beretta,Gabriela Riemekasten,Torsten Witte,Nicolas Hunzelmann,Alexander Kreuter,Jörg H W Distler,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Roger Hesselstrand,Annika Nordin,Paolo Airò,Claudio Lunardi,Paul G. Shiels,Jacob M van Laar,Ariane L. Herrick,Jane Worthington,Christopher P. Denton,Fredrick M. Wigley,Laura K. Hummers,John Varga,Monique Hinchcliff,Murray Baron,Marie Hudson,Janet E. Pope,Daniel E. Furst,Dinesh Khanna,Kristin Phillips,Elena Schiopu,Barbara M. Segal,Jerry A. Molitor,Richard M. Silver,Virginia D. Steen,Robert W. Simms,Robert Lafyatis,Barri J. Fessler,Tracy M. Frech,Firas Alkassab,Peter Docherty,Elzbieta Kaminska,Nader Khalidi,Henry Niall Jones,Janet Markland,David Robinson,Jasper C A Broen,Jasper C A Broen,Timothy R D J Radstake,Timothy R D J Radstake,Carmen Fonseca,Bobby P. C. Koeleman,Javier Martín +77 more
TL;DR: This study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
Journal ArticleDOI
A comparison of the frequency of antibodies to cyclic citrullinated peptides using a third generation anti-CCP assay (CCP3) in systemic sclerosis, primary biliary cirrhosis and rheumatoid arthritis
Mittermayer Barreto Santiago,Murray Baron,Kiyomitsu Miyachi,Marvin J. Fritzler,Maysan Abu-Hakima,Sharon LeClercq,Mary J. Bell,Marie Hudson,Jean-Pierre Mathieu,Suzanne S. Taillefer,Niall Jones,Peter Docherty,M. Khraishi,Janet Markland,Janet E. Pope,David Robinson,Denise L. Smith,E. Sutton +17 more
TL;DR: The high specificity and sensitivity of both anti-CCP assays for the diagnosis of RA were confirmed, and there was no association of anti- CCP2 or anti-ccP3 with anti-CENP B, anti-Scl 70, or RF.