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Barbara M. Segal
Researcher at University of Minnesota
Publications - 42
Citations - 2427
Barbara M. Segal is an academic researcher from University of Minnesota. The author has contributed to research in topics: Genome-wide association study & Depression (differential diagnoses). The author has an hindex of 23, co-authored 42 publications receiving 2078 citations. Previous affiliations of Barbara M. Segal include Hennepin County Medical Center.
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Journal ArticleDOI
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.
Christopher J. Lessard,Christopher J. Lessard,He Li,He Li,Indra Adrianto,John A. Ice,Astrid Rasmussen,Kiely Grundahl,Jennifer A. Kelly,Mikhail G. Dozmorov,Corinne Miceli-Richard,Simon J. Bowman,Susan C. Lester,Per Eriksson,Maija-Leena Eloranta,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Marika Kvarnström,Helmi Jazebi,Helmi Jazebi,Deborah S. Cunninghame Graham,Martha E. Grandits,Abu N. M. Nazmul-Hossain,Ketan Patel,Adam Adler,Jacen S. Maier-Moore,Jacen S. Maier-Moore,A. Darise Farris,Michael T. Brennan,James A. Lessard,James Chodosh,Rajaram Gopalakrishnan,Kimberly S. Hefner,Glen D Houston,Andrew J.W. Huang,Pamela J. Hughes,David M Lewis,Lida Radfar,Michael D. Rohrer,Donald U. Stone,Jonathan D. Wren,Timothy J. Vyse,Patrick M. Gaffney,Judith A. James,Judith A. James,Roald Omdal,Marie Wahren-Herlenius,Gabor G. Illei,Torsten Witte,Roland Jonsson,Maureen Rischmueller,Lars Rönnblom,Gunnel Nordmark,Wan-Fai Ng,Xavier Mariette,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,R. Hal Scofield,Courtney G. Montgomery,John B. Harley,John B. Harley,Kathy L. Sivils,Kathy L. Sivils +67 more
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Journal ArticleDOI
Peripheral blood gene expression profiling in Sjögren's syndrome.
Eshrat S. Emamian,Joanlise M. Leon,Joanlise M. Leon,Christopher J. Lessard,Christopher J. Lessard,Martha E. Grandits,Emily C. Baechler,Patrick M. Gaffney,Barbara M. Segal,Nelson L. Rhodus,Kathy L. Moser,Kathy L. Moser +11 more
TL;DR: The results strongly support innate and adaptive immune processes in the pathogenesis of SS, and provide numerous candidate disease markers for further study.
Journal ArticleDOI
Primary Sjögren's Syndrome: health experiences and predictors of health quality among patients in the United States.
Barbara M. Segal,Simon J. Bowman,Philip C. Fox,Frederick B. Vivino,Nandita Murukutla,Jeff Brodscholl,Sarika Ogale,Lachy McLean +7 more
TL;DR: Diminished health quality and excess health costs are prevalent among PSS patients and delayed diagnosis, sicca related morbidity, fatigue, pain and depression are substantial suggesting unmet health needs and the importance of earlier recognition of PSS.
Journal ArticleDOI
Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis
Maureen D. Mayes,Lara Bossini-Castillo,Olga Y. Gorlova,Jose Ezequiel Martin,Xiaodong Zhou,Wei V. Chen,Shervin Assassi,Jun Ying,Filemon K. Tan,Frank C. Arnett,John D. Reveille,Sandra G. Guerra,María Teruel,F.D. Carmona,Peter K. Gregersen,Annette Lee,Elena López-Isac,Eguzkine Ochoa,Patricia Carreira,Carmen P. Simeon,Ivan Castellví,Miguel A. González-Gay,Alexandra Zhernakova,Leonid Padyukov,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Cisca Wijmenga,Matthew A. Brown,Lorenzo Beretta,Gabriela Riemekasten,Torsten Witte,Nicolas Hunzelmann,Alexander Kreuter,Jörg H W Distler,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Roger Hesselstrand,Annika Nordin,Paolo Airò,Claudio Lunardi,Paul G. Shiels,Jacob M van Laar,Ariane L. Herrick,Jane Worthington,Christopher P. Denton,Fredrick M. Wigley,Laura K. Hummers,John Varga,Monique Hinchcliff,Murray Baron,Marie Hudson,Janet E. Pope,Daniel E. Furst,Dinesh Khanna,Kristin Phillips,Elena Schiopu,Barbara M. Segal,Jerry A. Molitor,Richard M. Silver,Virginia D. Steen,Robert W. Simms,Robert Lafyatis,Barri J. Fessler,Tracy M. Frech,Firas Alkassab,Peter Docherty,Elzbieta Kaminska,Nader Khalidi,Henry Niall Jones,Janet Markland,David Robinson,Jasper C A Broen,Jasper C A Broen,Timothy R D J Radstake,Timothy R D J Radstake,Carmen Fonseca,Bobby P. C. Koeleman,Javier Martín +77 more
TL;DR: This study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
Journal ArticleDOI
Comparison of the American-European Consensus Group Sjögren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort
Astrid Rasmussen,John A. Ice,He Li,He Li,Kiely Grundahl,Jennifer A. Kelly,Lida Radfar,Donald U. Stone,Kimberly S. Hefner,Juan-Manuel Anaya,Michael D. Rohrer,Rajaram Gopalakrishnan,Glen D Houston,David M Lewis,James Chodosh,John B. Harley,John B. Harley,Pamela J. Hughes,Jacen S. Maier-Moore,Courtney G. Montgomery,Nelson L. Rhodus,A. Darise Farris,Barbara M. Segal,Roland Jonsson,Christopher J. Lessard,Christopher J. Lessard,R. Hal Scofield,Kathy L. Sivils +27 more
TL;DR: It is contention that improvements in diagnostic acumen will require a more fundamental understanding of the pathogenic mechanisms than is at present available and there is no clear evidence for increased value of the new ACR criteria over the old AECG criteria from the clinical or biological perspective.