J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
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Journal ArticleDOI
Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy.
Dominique Arion,Michael Sabatini,Travis Unger,Jesús Pastor,Lidia Alonso-Nanclares,Inmaculada Ballesteros-Yáñez,Rafael G. Sola,Alberto Muñoz,Karoly Mirnics,Javier DeFelipe +9 more
TL;DR: It is concluded that abnormal electrical brain activity in the spiking samples is strongly correlated with gene expression changes and some of the observed transcriptome changes may be directly involved in the induction or prevention of the ictal events seen in epilepsy.
Journal ArticleDOI
Microanatomy of the dysplastic neocortex from epileptic patients
Lidia Alonso-Nanclares,Rita Garbelli,Rafael G. Sola,Jesús Pastor,Laura Tassi,Roberto Spreafico,Javier DeFelipe +6 more
TL;DR: The results suggest that cortical dysplasia leads to multiple changes in excitatory and inhibitory synaptic circuits, and the possible relationship between these alterations and epilepsy is discussed.
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Demonstration of glutamate-positive axon terminals forming asymmetric synapses in cat neocortex.
TL;DR: Electron microscopic examination of sections immunocytochemically processed with an anti-glutamate serum reveals that many asymmetric synapses in the cat neocortex contain elevated levels of immunodetectable glutamate.
Journal ArticleDOI
Synaptic Connections of Calretinin-Immunoreactive Neurons in the Human Neocortex
M. del Rio,Javier DeFelipe +1 more
TL;DR: The results indicate that different subpopulations of CR interneurons exist that are specialized for selective innervation of somatic or dendritic regions of certain pyramidal and nonpyramidal neurons.
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Parvalbumin immunoreactivity reveals layer IV of monkey cerebral cortex as a mosaic of microzones of thalamic afferent terminations.
Javier DeFelipe,Edward G. Jones +1 more
TL;DR: Correlative observations in the present and other studies indicate that the aggregations of PV-immunoreactive terminals forming asymmetric synapses arise from thalamic afferent fibers while those forming symmetric synapse arise from intrinsic gamma-aminobutyric acid neurons.