J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
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Journal ArticleDOI
Random positions of dendritic spines in human cerebral cortex
Juan Morales,Ruth Benavides-Piccione,Mor Dar,Isabel Fernaud,Angel Rodríguez,Laura Anton-Sanchez,Concha Bielza,Pedro Larrañaga,Javier DeFelipe,Rafael Yuste +9 more
TL;DR: It is concluded that in adult human neocortex spine positions are mostly random, either in apical or basal dendrites, in neurons of different cortical areas or among spines of different volumes and lengths.
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Specialization in pyramidal cell structure in the sensory-motor cortex of the Chacma baboon (Papio ursinus) with comparative notes on macaque and vervet monkeys.
TL;DR: A progressive increase in the morphological complexity of pyramidal cells is found through areas 3b, 5, and 7, as well as from area 4 to area 6, suggesting that areal specialization in microcircuitry was likely to be present in a common ancestor of primates.
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Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice
Britt Mellström,Asta Kastanauskaite,Shira Knafo,Shira Knafo,Paz Gonzalez,Xose M. Dopazo,Ana Ruiz-Nuño,John G. R. Jefferys,Min Zhuo,Min Zhuo,Timothy V. P. Bliss,Jose R. Naranjo,Javier DeFelipe +12 more
TL;DR: It is shown that potentiating DREAM activity, by overexpressing daDREAM, reduced dendritic basal arborization and spine density in CA1 pyramidal neurons and increased spinedensity in dendrites in dentate gyrus granule cells, suggesting that DREAM plays an important role in structural plasticity in the hippocampus.
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Specialization in pyramidal cell structure in the cingulate cortex of the Chacma baboon (Papio ursinus): an intracellular injection study of the posterior and anterior cingulate gyrus with comparative notes on the macaque and vervet monkeys.
TL;DR: The complexity in pyramidal cell structure in both the anterior and posterior cingulate gyrus of the baboon differed to that in the corresponding regions in either the macaque or vervet monkeys.
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Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex
Carlos Sánchez,Jon I. Arellano,P Rodríguez-Sánchez,Jesús Avila,Javier DeFelipe,F. J. Díez-Guerra +5 more
TL;DR: It is proposed that MAP2 phosphorylation is decreased in the neocortex of epileptic patients and that this decrease is a likely consequence of seizure activity.