J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
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Journal ArticleDOI
A Fast Method for the Segmentation of Synaptic Junctions and Mitochondria in Serial Electron Microscopic Images of the Brain
Pablo Márquez Neila,Luis Baumela,Juncal González-Soriano,José-Rodrigo Rodríguez,Javier DeFelipe,Angel Merchán-Pérez +5 more
TL;DR: This work presents a method that works with anisotropic voxels and that is computationally efficient allowing the segmentation of large image stacks and introduces high-level knowledge about the structure of labels in EM stacks from the cerebral cortex through anisotropy-aware regularization.
Journal ArticleDOI
Morphometric alterations of Golgi apparatus in Alzheimer's disease are related to tau hyperphosphorylation.
Alejandro Antón-Fernández,Guillermo Aparicio-Torres,Silvia Tapia,Javier DeFelipe,Alberto Muñoz,Alberto Muñoz,Alberto Muñoz +6 more
TL;DR: Findings support the idea that the progressive accumulation of phospho-tau is associated with structural alterations of the GA including fragmentation and a decrease in the surface area and volume of GA elements in neurons in Alzheimer's disease patients.
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Changes in tau phosphorylation in hibernating rodents
Gonzalo León-Espinosa,Gonzalo León-Espinosa,Esther García,Vega García-Escudero,Félix Hernández,Javier DeFelipe,Javier DeFelipe,Jesús Avila +7 more
TL;DR: This work has compared the sequence of Syrian hamster tau with the sequences of other hibernating and nonhibernating rodents and investigated how differences in the N‐terminal region of tau could affect the phosphorylation level and tau binding to cell membranes.
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Towards a supervised classification of neocortical interneuron morphologies
Bojan Mihaljević,Pedro Larrañaga,Ruth Benavides-Piccione,Sean Hill,Sean Hill,Javier DeFelipe,Concha Bielza +6 more
TL;DR: This study trains models using 217 high-quality morphologies of rat somatosensory neocortex interneurons reconstructed by a single laboratory and pre-classified into eight types, characterized with interpretable models or with up to ten morphometrics.
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Local connections in transplanted and normal cerebral cortex of rats
TL;DR: In the neocortical transplants there is a pattern of local connectivity that is reminiscent of the pattern of intracortical connectivity in the normal neocortex in at least two aspects: first, the retrograde-labeled cells tended to form clusters or bands; second, both pyramidal and non-pyramidal cells were labeled.