J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
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Journal ArticleDOI
Selective Changes in the Microorganization of the Human Epileptogenic Neocortex Revealed by Parvalbumin Immunoreactivity
Javier DeFelipe,Rafael G. Sola,Pilar Marco,Marı́a R. del Rı́o,Paloma Pulido,Santiago Ramón y Cajal +5 more
TL;DR: The microanatomy of the human lateral temporal cortex removed from patients with intractable temporal lobe epilepsy was studied and PV immunostaining was mainly used to label a subpopulation of powerful cortical inhibitory interneurons that have been shown to be lost at epileptic foci in certain animal models of epilepsy.
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Human Cortical Pyramidal Neurons: From Spines to Spikes via Models.
Guy Eyal,Matthijs B. Verhoog,Matthijs B. Verhoog,Guilherme Testa-Silva,Yair Deitcher,Ruth Benavides-Piccione,Javier DeFelipe,Christiaan P. J. de Kock,Huibert D. Mansvelder,Idan Segev +9 more
TL;DR: This study provides the most comprehensive model of any human neuron to-date demonstrating the biophysical and computational distinctiveness of human cortical neurons.
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Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors.
Inmaculada Ballesteros-Yáñez,Ruth Benavides-Piccione,Jean-Pierre Bourgeois,Jean-Pierre Changeux,Javier DeFelipe +4 more
TL;DR: The data suggest that the β2-subunit is involved in the dendritic morphogenesis of pyramidal neurons and, in particular, in the circuits that contribute to the high-order functional connectivity of the cerebral cortex.
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Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse.
Ruth Benavides-Piccione,Mara Dierssen,Inmaculada Ballesteros-Yáñez,M. Martinez de Lagran,M.L. Arbonés,Vassiliki Fotaki,Javier DeFelipe,Guy N. Elston +7 more
TL;DR: The microstructure of cortical circuitry in the Dyrk1A+/- mouse and control littermates by intracellular injection of Lucifer Yellow in fixed cortical tissue is analyzed and it is found that labeled pyramidal cells were considerably smaller, less branched and less spinous in the cortex of DyrK1A-/- mice than in control littermate.
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Patterns of synaptic input on corticocortical and corticothalamic cells in the cat visual cortex. I. The cell body.
Isabel Fariñas,Javier DeFelipe +1 more
TL;DR: The data suggest that callosal cells receive more inhibition than corticothalamic cells at the level of their somata, and that within each population of pyramidal cells there was variability in the number and density of axosomatic synapses.