Javier DeFelipe

TL;DR: A semi-supervised projected clustering algorithm based on finite mixture models and the expectation-maximization algorithm, that is useful for classifying neuron types, is proposed, reporting results for known classes and possible new groups of interneurons.

TL;DR: In this article , a method for human brain fixation based on simultaneous perfusion of 4% paraformaldehyde through carotids after a flush with saline was presented. But this procedure resulted in similar morphological features to those obtained by intravascular perfusion in experimental animals, provided that the postmortem interval was under 10 h for several of the techniques used and under 4 h in the case of intracellular injections and electron microscopy.

TL;DR: This report provides evidence for the presence of SP-like immunoreactivity in cortical cells, based upon immunocytochemistry using an antiserum directed against other sequences of SP, and shows that there are two populations of putative SP cortical neurons.

TL;DR: InTool Explorer provides a new opportunity to study and analyze neuroscience data prior to any statistical analysis being carried out, and allows fast visualization of the data, error finding, and re-evaluation to establish new hypotheses or new lines of research.

TL;DR: Three complementary protocols to follow the development of tau pathology in Alzheimer's disease are described and it is suggested that characterization of phosphorylated tau in detergent-insoluble protein aggregates could also be an indication of the neuropathological staging in AD.