J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
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Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR 5/6/7 in the human epileptogenic neocortex.
TL;DR: The results indicate that in the human epileptogenic neocortex there may be alterations in particular excitatory and/or inhibitory synaptic systems at small, multiple neocortical foci, and that these alterations are found mostly in the same regions.
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Neocortical circuits: evolutionary aspects and specificity versus non-specificity of synaptic connections. Remarks, main conclusions and general comments and discussion.
Javier DeFelipe,Guy N. Elston,Ichiro Fujita,Joaquin M. Fuster,Kimberly H. Harrison,Patrick R. Hof,Yasuo Kawaguchi,Kevan A. C. Martin,Kathleen S. Rockland,Alex M. Thomson,Samuel S.-H. Wang,Edward L. White,Rafael Yuste +12 more
TL;DR: This paper presents a meta-anatomical analysis of the response of the immune cells to Tournaisian reprograming, which has implications for the design of prosthetic connective tissue.
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Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease.
Lidia Blazquez-Llorca,Virginia García-Marín,Paula Merino-Serrais,Paula Merino-Serrais,Jesús Avila,Javier DeFelipe,Javier DeFelipe +6 more
TL;DR: It is presented here the rather unexpected discovery that in AD, there is conspicuous abnormal phosphorylation of the tau protein in a selective subset of dendritic spines that are typical thorny excrescences of hippocampal CA3 neurons in a pre-tangle state.
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Spatial distribution of neurons innervated by chandelier cells
Lidia Blazquez-Llorca,Alan Woodruff,Melis Inan,Stewart A. Anderson,Rafael Yuste,Javier DeFelipe,Javier DeFelipe,Angel Merchán-Pérez +7 more
TL;DR: This work made use of a genetic targeting strategy to label neocortical ChCs in upper layers of juvenile mouse neocortex to examine the circuit connectivity of chandelier cells and found that individual ChCs may exert a strong, widespread influence on their local pyramidal neighbors in a spatially heterogeneous fashion.
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Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients
Marta Dominguez-Alvaro,M. Montero-Crespo,M. Montero-Crespo,Lidia Blazquez-Llorca,Lidia Blazquez-Llorca,Ricardo Insausti,Javier DeFelipe,Javier DeFelipe,Lidia Alonso-Nanclares,Lidia Alonso-Nanclares +9 more
TL;DR: There is a dramatic loss of absolute number of synapses in the TEC of patients with AD, while the morphology of synaptic junctions and synaptic spatial distribution are maintained, and how these changes affect cognitive impairment in AD remains to be elucidated.