J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
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Book ChapterDOI
Computer assisted identification, segmentation and quantification of synapses in the cerebral cortex
Juan Morales,Lidia Alonso-Nanclares,José-Rodrigo Rodríguez,Angel Merchán-Pérez,Javier DeFelipe,Angel Rodríguez +5 more
TL;DR: A software tool is developed to automatically perform the segmentation of synapses in a reconstructed 3D volume of the cerebral cortex, thereby greatly facilitating and accelerating these processes.
Book ChapterDOI
A Model of Human Cortical Microcircuits for the Study of the Development of Epilepsy
Manuel A. Sánchez-Montañés,Luis F. Lago-Fernández,Nazareth P. Castellanos,Angel Merchán-Pérez,Jon I. Arellano,Javier DeFelipe +5 more
TL;DR: In this paper, the authors used computer simulations to test the hypothesis that the loss of chandelier cells, which are powerful inhibitory interneurons, might be a key element in the development of seizures in epileptic patients.
Posted ContentDOI
Dendritic spines are lost in clusters in patients with Alzheimer’s disease
Mite Mijalkov,Giovanni Volpe,Isabel Fernaud-Espinosa,Isabel Fernaud-Espinosa,Javier DeFelipe,Javier DeFelipe,Joana B. Pereira,Joana B. Pereira,Paula Merino-Serrais,Paula Merino-Serrais +9 more
TL;DR: It is shown that the presence of tau pathology determines the loss of dendritic spines in blocks, ruling out alternative models where spine loss occurs randomly.
Posted ContentDOI
Dendritic spines are lost in clusters in Alzheimer’s disease
Mite Mijalkov,Giovanni Volpe,Isabel Fernaud-Espinosa,Isabel Fernaud-Espinosa,Javier DeFelipe,Javier DeFelipe,Joana B. Pereira,Joana B. Pereira,Paula Merino-Serrais,Paula Merino-Serrais +9 more
TL;DR: In this paper, the authors used graph-theory approaches to compare the distribution of dendritic spines from neurons with and without tau pathology in individuals with Alzheimer's disease.
Journal ArticleDOI
Cell specificity of altered cation-chloride cotransporter expression and GABAergic innervation in the epileptic cerebral cortex
Alberto Muñoz,Javier DeFelipe +1 more
TL;DR: Brain tissue from patients with medically intractable epilepsy associated with different types of malformations, including focal cortical dysplasia type IIB, hemimegalencephaly and ganglioglioma was studied to determine whether the deregulation of cation–chloride cotransporter expression might contribute to the hyperexcitability that leads to seizures.