J
Javier DeFelipe
Researcher at Technical University of Madrid
Publications - 350
Citations - 23301
Javier DeFelipe is an academic researcher from Technical University of Madrid. The author has contributed to research in topics: Neocortex & Dendritic spine. The author has an hindex of 76, co-authored 327 publications receiving 20464 citations. Previous affiliations of Javier DeFelipe include Spanish National Research Council & University of California, Irvine.
Papers
More filters
Journal ArticleDOI
A correlative electron microscopic study of basket cells and large gabaergic neurons in the monkey sensory-motor cortex
TL;DR: Large glutamate decarboxylase-positive neurons of the same size as those positively identified as basket cells in the Golgi and horseradish peroxidase material have virtually the same morphological characteristics, at both the light and electron microscope levels, as the basket cells.
Journal ArticleDOI
Age-Based Comparison of Human Dendritic Spine Structure Using Complete Three-Dimensional Reconstructions
TL;DR: This study assembled a large, quantitative database, which revealed a major reduction in spine densities in the aged case, suggesting selective alterations in spines with aging in humans and indicating that the spine volume and length are regulated by different biological mechanisms.
Journal ArticleDOI
Double bouquet cell in the human cerebral cortex and a comparison with other mammals.
Inmaculada Ballesteros Yáñez,Alberto Muñoz,Alberto Muñoz,Julio Contreras,Juncal Gonzalez,Elisia Rodríguez-Veiga,Javier DeFelipe +6 more
TL;DR: It is concluded that, although these interneurons may be an important element in the organization of cortical microcolumns in primates, this is not the case in other mammalian species.
Journal ArticleDOI
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
TL;DR: It is shown for the first time that there is no correlation between total neuronal loss and PV-ir neuronal loss in any of the hippocampal fields and the apparently normal subiculum from sclerotic patients also shows unexpected changes in the density and proportion of PV-IR neurons.
Journal ArticleDOI
Widespread Changes in Dendritic Spines in a Model of Alzheimer's Disease
Shira Knafo,Lidia Alonso-Nanclares,Juncal González-Soriano,Paula Merino-Serrais,Isabel Fernaud-Espinosa,Isidro Ferrer,Javier DeFelipe +6 more
TL;DR: A substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice is revealed, which likely contributes to the cognitive impairments observed in this AD model.