Zheqi Li

TL;DR: The generation and characterization of genome-edited T47D and MCF7 breast cancer cell lines with the two most common ESR1 mutations are described, revealing ligand-independent growth and endocrine resistance and identifying novel target genes involved in metastasis-associated phenotypes.

TL;DR: The first discovery of naturally occurring ESR1Y537C and ESR2Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estrogen-deprivation and subsequent resistance to fulvestrant is reported.

TL;DR: In this article , a bank of human patient-derived xenografts and matched organoid cultures from tumors that represent the greatest unmet need: endocrine-resistant, treatment-refractory and metastatic breast cancers are reported.

TL;DR: A comprehensive 2D and 3D phenotypic characterization of four estrogen receptor-positive human ILC cell lines confirmed the decreased cell proliferation and E-cadherin-mediated intercellular junctions in ILC while uncovering the induction of novel pathways related to cyclic nucleotide phosphodiesterase activity, ion channels, drug metabolism, and alternative cell adhesion molecules.

TL;DR: A critical role of enhanced IGF1 signaling in ESR1 mutant cell lines is supported, pointing toward a potential for cotargeting IGF1R and ERα in endocrine-resistant breast tumors with mutant E SR1.