J
Jeffrey M. Peters
Researcher at Pennsylvania State University
Publications - 217
Citations - 21665
Jeffrey M. Peters is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Receptor. The author has an hindex of 74, co-authored 214 publications receiving 20405 citations. Previous affiliations of Jeffrey M. Peters include Lawrence Livermore National Laboratory & National Institutes of Health.
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Journal ArticleDOI
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Sander Kersten,Josiane Seydoux,Jeffrey M. Peters,Frank J. Gonzalez,Béatrice Desvergne,Walter Wahli +5 more
TL;DR: It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.
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The PPARalpha-leukotriene B4 pathway to inflammation control.
Pallavi R. Devchand,Hansjörg Keller,Jeffrey M. Peters,Manuel Vázquez,Frank J. Gonzalez,Walter Wahli +5 more
TL;DR: Because PPARα regulates the oxidative degradation of fatty acids and their derivatives, like this lipid mediator, a feedback mechanism is proposed that controls the duration of an inflammatory response and the clearance of leukotriene B4 in the liver.
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Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
Philippe Delerive,Karolien De Bosscher,Sandrine Besnard,Wim Vanden Berghe,Jeffrey M. Peters,Frank J. Gonzalez,Jean Charles Fruchart,Alain Tedgui,Guy Haegeman,Bart Staels +9 more
TL;DR: Fibrates inhibit the vascular inflammatory response via PPARα by interfering with the NF-κB and AP-1 transactivation capacity involving direct protein-protein interaction with p65 and c-Jun.
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Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)
Toshifumi Aoyama,Jeffrey M. Peters,Nobuko Iritani,Tamie Nakajima,Kenichi Furihata,Takashi Hashimoto,Frank J. Gonzalez +6 more
TL;DR: PPARα modulates constitutive expression of genes encoding several mitochondrial fatty acid-catabolizing enzymes in addition to mediating inducible mitochondrial and peroxisomal fatty acid β-oxidation, thus establishing a role for the receptor in fatty acid homeostasis.
Journal ArticleDOI
Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)
Jeffrey M. Peters,Susanna S.T. Lee,Wen Li,Jerrold M. Ward,Oksana Gavrilova,Carrie Everett,Marc L. Reitman,Lynn D. Hudson,Frank J. Gonzalez +8 more
TL;DR: These results are the first to provide in vivo evidence of significant roles for PPARβ in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.