J
Jennifer L. Moran
Researcher at Broad Institute
Publications - 119
Citations - 41227
Jennifer L. Moran is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome-wide association study & Copy-number variation. The author has an hindex of 54, co-authored 114 publications receiving 33978 citations. Previous affiliations of Jennifer L. Moran include Scott & White Hospital & University of Illinois at Chicago.
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Journal ArticleDOI
The penetrance of copy number variations for schizophrenia and developmental delay
George Kirov,Elliott Rees,James T.R. Walters,Valentina Escott-Price,Lyudmila Georgieva,Alexander Richards,Kimberly Chambert,Gerwyn Davies,Sophie E. Legge,Jennifer L. Moran,Steven A. McCarroll,Michael Conlon O'Donovan,Michael John Owen +12 more
TL;DR: The overall penetrance of SCZ-associated CNVs for developing any disorder is high, ranging between 10.6% and 100%, and the rates of nearly all CNVs are higher in DD/ASD/CM compared with SCZ.
Journal ArticleDOI
Copy number variation in schizophrenia in Sweden
Jin P. Szatkiewicz,Colm O'Dushlaine,Guanhua Chen,Kimberly Chambert,Jennifer L. Moran,Benjamin M. Neale,Menachem Fromer,Douglas M. Ruderfer,Susanne Akterin,Sarah E. Bergen,Anna K. Kähler,Patrik K. E. Magnusson,Yunjung Kim,James J. Crowley,Elliott Rees,George Kirov,Michael Conlon O'Donovan,Michael John Owen,James T.R. Walters,Edward M. Scolnick,Pamela Sklar,Shaun Purcell,Christina M. Hultman,Steven A. McCarroll,Patrick F. Sullivan +24 more
TL;DR: Increases in burden of the largest CNVs in genes present in the postsynaptic density, in genomic regions implicated via SCZ genome-wide association studies and in gene products localized to mitochondria and cytoplasm suggest that multiple lines of genomic inquiry are converging on similar sets of pathways and/or genes.
Journal ArticleDOI
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
Sarah E. Bergen,Colm O'Dushlaine,Colm O'Dushlaine,Stephan Ripke,Stephan Ripke,Phil Lee,Phil Lee,Douglas M. Ruderfer,Douglas M. Ruderfer,Susanne Akterin,Jennifer L. Moran,Kimberly Chambert,Robert E. Handsaker,Robert E. Handsaker,Lena Backlund,Urban Ösby,Steven A. McCarroll,Steven A. McCarroll,Mikael Landén,Mikael Landén,Edward M. Scolnick,Patrik K. E. Magnusson,Paul Lichtenstein,Christina M. Hultman,Shaun Purcell,Pamela Sklar,Pamela Sklar,Pamela Sklar,Patrick F. Sullivan +28 more
TL;DR: Combining new and previously reported SCZ samples revealed a genome-wide significant association in the major histocompatibility complex (MHC) region, which reinforces prior reports of significant MHC and CNV associations in SCZ, but not BD.
Journal ArticleDOI
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies
Bogdan Pasaniuc,Bogdan Pasaniuc,Nadin Rohland,Nadin Rohland,Paul J. McLaren,Paul J. McLaren,Kiran V. Garimella,Noah Zaitlen,Noah Zaitlen,Heng Li,Namrata Gupta,Benjamin M. Neale,Benjamin M. Neale,Mark J. Daly,Mark J. Daly,Pamela Sklar,Patrick F. Sullivan,Sarah E. Bergen,Jennifer L. Moran,Christina M. Hultman,Paul Lichtenstein,Patrik K. E. Magnusson,Shaun Purcell,Shaun Purcell,David W. Haas,Liming Liang,Liming Liang,Shamil R. Sunyaev,Shamil R. Sunyaev,Nick Patterson,Paul I.W. de Bakker,David Reich,David Reich,Alkes L. Price,Alkes L. Price +34 more
TL;DR: It is shown that extremely low-coverage sequencing captures almost as much of the common and low-frequency variation across the genome as SNP arrays, within the context of reductions in sample preparation and sequencing costs.
Posted ContentDOI
Discovery Of The First Genome-Wide Significant Risk Loci For ADHD
Ditte Demontis,Raymond K. Walters,Joanna Martin,Manuel Mattheisen,Thomas Damm Als,Esben Agerbo,Rich Belliveau,Jonas Bybjerg-Grauholm,Marie Bækvad-Hansen,Felecia Cerrato,Kimberly Chambert,Claire Churchhouse,Ashley Dumont,Nicholas Eriksson,Michael J. Gandal,Jacqueline I. Goldstein,Jakob Grove,Christine Søholm Hansen,Mads E. Hauberg,Mads V. Hollegaard,Daniel P. Howrigan,Hailiang Huang,Julian Maller,Jennifer L. Moran,Jonatan Pallesen,Duncan S. Palmer,Carsten Bøcker Pedersen,Timothy Poterba,Jesper Buchhave Poulsen,Stephan Ripke,Elise B. Robinson,F. Kyle Satterstrom,Christine Stevens,Patrick Turley,Hyejung Won,Ole A. Andreassen,Christie L. Burton,Dorret I. Boomsma,Bru Cormand,Søren Dalsgaard,Barbara Franke,Joel Gelernter,Daniel H. Geschwind,Hakon Hakonarson,Jan Haavik,Henry R. Kranzler,Jonna Kuntsi,Kate Langley,Klaus-Peter Lesch,Christel M. Middeldorp,Andreas Reif,Luis Augusto Rohde,Panos Roussos,Russell Schachar,Pamela Sklar,Edmund J.S. Sonuga-Barke,Patrick F. Sullivan,Anita Thapar,Joyce Y. Tung,Irwin D. Waldman,Merete Nordentoft,David M. Hougaard,Thomas Werge,Ole Mors,Preben Bo Mortensen,Mark J. Daly,Stephen V. Faraone,Anders D. Børglum,Benjamin M. Neale +68 more
TL;DR: The hypothesis that clinical diagnosis of ADHD is an extreme expression of one or more continuous heritable traits is supported, supported by additional analyses of a self-reported ADHD sample and a study of quantitative measures of ADHD symptoms in the population.