Jill E. Gready

TL;DR: The superfamily of proteins containing C‐type lectin‐like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions that have evolved to specifically recognize protein, lipid and inorganic ligands, including the vertebrate clade‐specific snake venoms, and fish antifreeze and bird egg‐shell proteins.

TL;DR: It is found that genomes from two isolates shared only 90% of their predicted genes, and divergence appears to have been facilitated by selection and acquisition processes that actively shape the repertoire of genes that are mutually exclusive between the two isolate differently than the core genes.

TL;DR: This review focuses on applications and protocols of recent studies where docking calculations and molecular dynamics simulations were combined to dock small molecules into protein receptors, and is structured to lead the reader from the simpler to more compute‐intensive methods.

TL;DR: This tool will stimulate future work to assess the impact of the quality of the PME approximation on simulation outcomes, particularly with regard to the trade‐off between cost and scientific reliability in biomolecular applications.

TL;DR: Analysis of sequence alignments and secondary structure predictions suggest that heparanase is a member of the clan A glycosyl hydrolases and has a common catalytic mechanism that involves two conserved acidic residues, a putative proton donor at Glu(225) and a nucleophile at GLU(343).