J
Jin Xin Bei
Researcher at Sun Yat-sen University
Publications - 66
Citations - 3298
Jin Xin Bei is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Nasopharyngeal carcinoma & Nasopharyngeal neoplasm. The author has an hindex of 27, co-authored 59 publications receiving 2688 citations. Previous affiliations of Jin Xin Bei include Agency for Science, Technology and Research & Genome Institute of Singapore.
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Journal ArticleDOI
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
Jin Xin Bei,Yi Li,Wei Hua Jia,Bing Jian Feng,Bing Jian Feng,Gangqiao Zhou,Li Zhen Chen,Qi Sheng Feng,Hui Qi Low,Hongxing Zhang,Fuchu He,E. Shyong Tai,Tiebang Kang,Edison T. Liu,Jianjun Liu,Yi Xin Zeng +15 more
TL;DR: The findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules.
Journal ArticleDOI
Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation
Jieming Chen,Hou-Feng Zheng,Hou-Feng Zheng,Jin Xin Bei,Liangdan Sun,Liangdan Sun,Wei Hua Jia,Tao Li,Tao Li,Furen Zhang,Mark Seielstad,Mark Seielstad,Mark Seielstad,Yi Xin Zeng,Xuejun Zhang,Xuejun Zhang,Jianjun Liu +16 more
TL;DR: Using over 350,000 genome-wide autosomal SNPs in over 6000 Han Chinese samples from ten provinces of China, this study revealed a one-dimensional "north-south" population structure and a close correlation between geography and the genetic structure of the Han Chinese.
Journal ArticleDOI
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
Tammy Song,Maarja-Liisa Nairismagi,Yurike Laurensia,Jing Quan Lim,Jing Tan,Zhi Mei Li,Wan Lu Pang,Atish Kizhakeyil,Giovani Claresta Wijaya,Dachuan Huang,Sanjanaa Nagarajan,Burton Kuan Hui Chia,Daryl Ming Zhe Cheah,Yan Hui Liu,Fen Zhang,Hui Lan Rao,Tiffany Tang,Esther Kam Yin Wong,Jin Xin Bei,Jabed Iqbal,Jabed Iqbal,Nicholas Francis Grigoropoulos,Siok Bian Ng,Wee Joo Chng,Bin Tean Teh,Soo Yong Tan,Navin Kumar Verma,Hao Fan,Hao Fan,Soon Thye Lim,Choon Kiat Ong +30 more
TL;DR: It is demonstrated that STAT3 activation confers high PD-L1 expression, which may promote tumor immune evasion and the combination of PD-1/PD-L 1 antibodies and STAT3 inhibitors might be a promising therapeutic approach for NKTL, and possibly PTCL.
Journal ArticleDOI
GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers
Shengping Li,Ji Qian,Yuan Yang,Wanting Zhao,Juncheng Dai,Jin Xin Bei,Jia Nee Foo,Paul J. McLaren,Zhiqiang Li,Jingmin Yang,Feng Shen,Li Liu,Jia-mei Yang,S. W. Li,Shandong Pan,Yi Wang,Wenjin Li,Xiangjun Zhai,Boping Zhou,Lehua Shi,Xinchun Chen,Minjie Chu,Yi-Qun Yan,Jun Wang,Shu-Qun Cheng,Jiawei Shen,Wei Hua Jia,Jibin Liu,Jiahe Yang,Zujia Wen,Ai-jun Li,Ying Zhang,Guoliang Zhang,Xianrong Luo,Hongbo Qin,Minshan Chen,Hua Wang,Li Jin,Dongxin Lin,Hongbing Shen,Lin He,Lin He,Lin He,Paul I.W. de Bakker,Hongyang Wang,Yi Xin Zeng,Meng-Chao Wu,Zhibin Hu,Yongyong Shi,Jianjun Liu,Weiping Zhou +50 more
TL;DR: A large three-stage GWAS in the Han Chinese population revealed the associations of HLA-DRB1*0405 and 0901*0602, which could partially account for the association at rs9272105, and implicates GRIK1 as a novel susceptibility gene for HBV–related HCC.
Journal ArticleDOI
New loci and coding variants confer risk for age-related macular degeneration in East Asians
Ching-Yu Cheng,Kenji Yamashiro,Li Jia Chen,Jeeyun Ahn,Lulin Huang,Lvzhen Huang,Chui Ming Gemmy Cheung,Masahiro Miyake,Peter Cackett,Ian Yeo,Augustinus Laude,Ranjana Mathur,Junxiong Pang,Kar Seng Sim,Adrian Koh,Peng Chen,Shu Yen Lee,Doric Wong,Choi Mun Chan,Boon Kwang Loh,Yaoyao Sun,Sonia Davila,Isao Nakata,Hideo Nakanishi,Yumiko Akagi-Kurashige,Norimoto Gotoh,Akitaka Tsujikawa,Fumihiko Matsuda,Keisuke Mori,Shin Yoneya,Yoichi Sakurada,Hiroyuki Iijima,Tomohiro Iida,Shigeru Honda,Timothy Y Y Lai,Pancy O. S. Tam,Haoyu Chen,Shibo Tang,Xiaoyan Ding,Feng Wen,Fang Lu,Xiongze Zhang,Yi Shi,Peiquan Zhao,Bowen Zhao,Jinghong Sang,Bo Gong,Rajkumar Dorajoo,Jian-Min Yuan,Woon-Puay Koh,Rob M. van Dam,Yechiel Friedlander,Ying Lin,Martin L. Hibberd,Jia Nee Foo,Ningli Wang,Chang Hua Wong,Gavin Tan,Sang Jun Park,Mayuri Bhargava,Lingam Gopal,Thet Naing,Jiemin Liao,Peng Guan Ong,Paul Mitchell,Peng Zhou,Xuefeng Xie,Jinlong Liang,Junpu Mei,Xin Jin,Seang-Mei Saw,Mineo Ozaki,Takanori Mizoguchi,Yasuo Kurimoto,Se Joon Woo,Hum Chung,Hyeong Gon Yu,Joo Young Shin,Dong Ho Park,In Taek Kim,Woohyok Chang,Min Sagong,Sang Joon Lee,Hyun Woong Kim,Ji Eun Lee,Yi Li,Jianjun Liu,Yik Ying Teo,Chew-Kiat Heng,Tock Han Lim,Suk-Kyun Yang,Kyuyoung Song,Eranga N. Vithana,Tin Aung,Jin Xin Bei,Yi Xin Zeng,E. Shyong Tai,Xiaoxin Li,Zhenglin Yang,Kyu Hyung Park,Chi Pui Pang,Nagahisa Yoshimura,Tien Yin Wong,Chiea Chuen Khor +103 more
TL;DR: The findings suggest that some of the genetic loci conferring AMD susceptibility in East Asians are shared with Europeans, yet AMD in East Asia may also have a distinct genetic signature.