Jo Rean D. Sicks

TL;DR: The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer.

TL;DR: More than 18% of all lung cancers detected by LDCT in the NLST seem to be indolent, and overdiagnosis should be considered when describing the risks of LDCT screening for lung cancer.

TL;DR: Low-dose CT was more sensitive in detecting early-stage lung cancers, but its measured positive predictive value was lower than that of radiography, and the two annual incidence screenings with low- dose CT resulted in a decrease in the number of advanced-stage cancers diagnosed and an increase in thenumber of early-Stage lung cancers diagnosed.

TL;DR: The work suggests that estimation of tumor shape currently is imprecise, even for experienced physicians, and there appears to be a practical limit to the current trend of smaller fields and tighter margins.

TL;DR: Analysis of metabolic response by 18F-FDG PET and objective response, glucose transporter type 4 (GLUT4) expression, and KIT/PDGFRA mutation status in patients with gastrointestinal stromal tumor undergoing neoadjuvant imatinib mesylate therapy suggests that GLUT4 may play a role in 18F/FDG uptake in gastrointestinal stomal tumor.