Mei Hsiu Chen

TL;DR: The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer.

TL;DR: In this study of asymptomatic adults, CT colonographic screening identified 90% of subjects with adenomas or cancers measuring 10 mm or more in diameter, augmenting published data on the role of CT colonography in screening patients with an average risk of colorectal cancer.

TL;DR: Comparing the accuracy of CT colonography in detecting histologically confirmed, large colorectal adenomas and cancers with findings on screening colonoscopy and histologic review, the reference standard shows that CT colonographic screening identified 90% of asymptomatic adults with adenoma and cancers ≥10 mm in diameter that were detected by screening colonoscope.

TL;DR: All three models predict CT colonography to be more costly and less effective than non-CT colonographic screening but net beneficial compared with no screening given model assumptions.

TL;DR: A significant difference in performance was observed among radiologists before formalized training, but testing and focused retraining improved radiologist performance, resulting in an overall high sensitivity across radiologists in a subsequent, prospective screening study.