J
Johan P. Turkenburg
Researcher at University of York
Publications - 126
Citations - 8279
Johan P. Turkenburg is an academic researcher from University of York. The author has contributed to research in topics: Hydrolase & Glycoside hydrolase. The author has an hindex of 41, co-authored 124 publications receiving 7492 citations. Previous affiliations of Johan P. Turkenburg include New York University & Newcastle University.
Papers
More filters
Journal ArticleDOI
A serine protease triad forms the catalytic centre of a triacylglycerol lipase.
Leo Brady,Andrzej M. Brzozowski,Andrzej M. Brzozowski,Zygmunt S. Derewenda,Eleanor J. Dodson,Guy Dodson,S.P. Tolley,Johan P. Turkenburg,Lars Christiansen,Birgitte Huge-Jensen,Leif Norskov,Lars Thim,Ulrich Menge +12 more
TL;DR: The X-ray structure of the Mucor miehei triglyceride lipase is reported and the atomic model obtained reveals a Ser .. His .. Asp trypsin-like catalytic triad with an active serine buried under a short helical fragment of a long surface loop.
Journal ArticleDOI
A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex
Andrzej M. Brzozowski,Andrzej M. Brzozowski,Urszula Derewenda,Urszula Derewenda,Zygmunt S. Derewenda,Zygmunt S. Derewenda,Guy Dodson,David M. R. Lawson,Johan P. Turkenburg,Fredrik Björkling,B. Huge-Jensen,S. A. Patkar,L. Thim +12 more
TL;DR: It is proposed that the structure of the enzyme in this complex of R. miehei lipase with n-hexylphosphonate ethyl ester is equivalent to the activated state generated by the oil–water interface.
Journal ArticleDOI
CCP4i2: the new graphical user interface to the CCP4 program suite.
Liz Potterton,Jon Agirre,Charles Ballard,Kevin Cowtan,Eleanor J. Dodson,Phil Evans,Huw T. Jenkins,Ronan M. Keegan,Eugene Krissinel,Kyle Stevenson,Andrey Lebedev,Stuart McNicholas,Robert A. Nicholls,Martin E.M. Noble,Navraj S. Pannu,Christian Roth,George M. Sheldrick,Pavol Skubák,Johan P. Turkenburg,Ville Uski,Frank von Delft,David G. Waterman,Keith S. Wilson,Martyn Winn,Marcin Wojdyr +24 more
TL;DR: CCP4i2 is a graphical user interface to the CCP4 (Collaborative Computational Project, Number 4) software suite and a Python language framework for software automation.
Journal ArticleDOI
Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase.
Andrzej M. Brzozowski,H Savage,Chandra S. Verma,Johan P. Turkenburg,D M Lawson,Allan Svendsen,Shamkant Anant Patkar +6 more
TL;DR: Five new Thermomyces (formerly Humicola) lanuginosa lipase (TlL) crystal structures have been solved and compared with four previously reported structures of this enzyme, suggesting that the sequence of the structural changes, as exemplified in various TlL crystal structures, mirror those that may occur during interfacial activation.
Journal ArticleDOI
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity
Rebecca J. Dennis,Edward J. Taylor,Matthew S. Macauley,Keith A. Stubbs,Johan P. Turkenburg,Sam Hart,Gary N Black,David J. Vocadlo,Gideon J. Davies +8 more
TL;DR: Mutagenesis and kinetics studies show that the bacterial enzyme, very similarly to its human counterpart, operates via an unusual 'substrate-assisted' catalytic mechanism, which will inform the rational design of enzyme inhibitors.